1-Palmitoyl-2-docosahexaenoyl-sn-glycero-3-PC (PDPC) is a phospholipid that contains palmitic acid and docosahexaenoic acid at the sn-1 and sn-2 positions, respectively. It is a component of LDL and HDL and has been found in atherosclerotic plaques.1,2 Enrichment of PDPC in recombinant HDLs decreases cholesterol ester formation by lecithin:cholesterol acyltransferase (LCAT) in vitro.3,4
1.Davis, B., Koster, G., Douet, L.J., et al.Electrospray ionization mass spectrometry identifies substrates and products of lipoprotein-associated phospholipase A2 in oxidized human low density lipoproteinJ. Biol. Chem.283(10)6428-6437(2008) 2.MÉnÉgaut, L., Masson, D., Abello, N., et al.Specific enrichment of 2-arachidonoyl-lysophosphatidylcholine in carotid atheroma plaque from type 2 diabetic patientsAtherosclerosis251339-347(2016) 3.Parks, J.S., Thuren, T.Y., and Schmitt, J.D.Inhibition of lecithin:cholesterol acyltransferase activity by synthetic phosphatidylcholine species containing eicosapentaenoic acid or docosahexaenoic acid in the sn-2 positionJ. Lipid Res.33(6)879-887(1992) 4.Parks, J.S., and Gebre, A.K.Long-chain polyunsaturated fatty acids in the sn-2 position of phosphatidylcholine decrease the stability of recombinant high density lipoprotein apolipoprotein A-I and the activation energy of the lecithin:cholesterol acyltransferase reactionJ. Lipid Res.38(2)266-275(1997)