1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt) (16:0/16:0-PA) is a phospholipid containing long-chain (16:0) palmitic acid inserted at the sn-1 and sn-2 positions, which can be used to prepare liposomes, micelles and artificial membranes[1, 2]. During retinoic acid and serum starvation-induced neuronal differentiation, diacylglycerol kinase z (DGKz) in mouse neuroblastoma Neuro-2a cells can specifically produce 1,2-Dipalmitoyl-sn-glycero-3-phosphate[3]. 1,2-Dipalmitoyl-sn-glycero-3-phosphate can bind to α-synuclein (α-syn)[4].
References:
[1] Sierra-Valdez F J, Forero-Quintero L S, Zapata-Morin P A, et al. The influence of non polar and polar molecules in mouse motile cells membranes and pure lipid bilayers[J]. PLoS One, 2013, 8(4): e59364.
[2] Jing W, Prenner E J, Vogel H J, et al. Headgroup structure and fatty acid chain length of the acidic phospholipids modulate the interaction of membrane mimetic vesicles with the antimicrobial peptide protegrin‐1[J]. Journal of Peptide Science: An Official Publication of the European Peptide Society, 2005, 11(11): 735-743.
[3] Sakane F, Mizuno S, Takahashi D, et al. Where do substrates of diacylglycerol kinases come from? Diacylglycerol kinases utilize diacylglycerol species supplied from phosphatidylinositol turnover-independent pathways[J]. Advances in biological regulation, 2018, 67: 101-108.
[4] Mizuno S, Sasai H, Kume A, et al. Dioleoyl‐phosphatidic acid selectively binds to α‐synuclein and strongly induces its aggregation[J]. FEBS letters, 2017, 591(5): 784-791.
1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt)（16:0/16:0-PA）是一种磷脂，含有插入到sn-1和sn-2位置的长链（16:0）棕榈酸，能够用于制备脂质体、胶束和人工膜[1, 2]。在视黄酸和血清饥饿诱导的神经元分化过程中，小鼠神经母细胞瘤Neuro-2a细胞中的二酰甘油激酶z（DGKz）能够特异性产生1,2-Dipalmitoyl-sn-glycero-3-phosphate[3]。1,2-Dipalmitoyl-sn-glycero-3-phosphate能够与α-突触核蛋白（α-syn）结合[4]。