1,2-Dioleoyl-sn-glycero-3-PS (DOPS) is a phospholipid containing oleic acid at the sn-1 and sn-2 positions, respectively. Nanovesicles composed of DOPS and the lysosomal protein saposin C (SapC) are cytotoxic to SK-MEL-28 cells in vitro and decrease tumor volume in a squamous cell carcinoma mouse xenograft model.[1] DOPS has been used in the formation of unilamellar vesicles to study the effect of curvature on membrane structure and in the formation of supported lipid bilayers to study the effects of various support materials on lipid redistribution between membrane leaflets.[2] [3]
Reference:
[1].Abu-Baker, S., Chu, Z., Stevens, A.M., et al.Cytotoxicity and selectivity in skin cancer by SapC-DOPS nanovesiclesJ. Cancer Ther.3(4)321-326(2012)
[2].Kucerka, N., Pencer, J., Sachs, J.N., et al.Curvature effect on the structure of phospholipid bilayersLangmuir23(3)1292-1299(2007)
[3].Richter, R.P., Maury, N., and Brisson, A.R.On the effect of the solid support on the interleaflet distribution of lipids in supported lipid bilayersLangmuir21(1)299-304(2005)