1,2,3-Trilinoleoyl-rac-glycerol is a triacylglycerol that contains linoleic acid at the sn-1, sn-2, and sn-3 positions. It reduces production of oxygen-derived free radicals in leukocytes.1 1,2,3-Trilinoleoyl-rac-glycerol (1 μM) reduces mitochondrial swelling and deformation induced by ischemia and reperfusion injury in perfused rat hearts. In vivo, 1,2,3-trilinoleoyl-rac-glycerol (1 mg/kg) reduces the incidence rate and duration of ventricular tachycardia, as well as infarct size in a rat model of coronary artery ligation-induced ischemia and reperfusion injury.2
|1. Chan, P., Niu, C.-S., Cheng, J.-T., et al. Trilinolein preserves mitochondria ultrastructure in isolated rat heart subjected to global ischemia through antioxidant activity as measured by chemiluminescence. Pharmacology 52(4), 216-225 (1996).|2. Chan, P., Tsai, S.-K., Chiang, B.-N., et al. Trilinolein reduces infarct size and suppresses ventricular arrhythmias in rats subjected to coronary ligation. Pharmacology 51(2), 118-126 (1995).