Uridine-d2 is intended for use as an internal standard for the quantification of uridine by GC- or LC-MS. Uridine is a pyrimidine nucleoside composed of uracil and ribose.1 It forms complementary base pairs with adenosine in RNA.2 Uridine can be catabolized to uracil via uridine phosphorylase, and it can be phosphorylated to uridine-5’-monophosphate by uridine-cytidine kinase (UCK).1,3 It is replaced with thymidine in DNA.4
1.Yamamoto, T., Koyama, H., Kurajoh, M., et al.Biochemistry of uridine in plasmaClin. Chim. Acta412(19-20)1712-1724(2011) 2.Zinshteyn, B., and Nishikura, K.Adenosine-to-inosine RNA editingWiley Interdiscip. Rev. Syst. Biol. Med.1(2)202-209(2009) 3.Van Rompay, A.R., Norda, A., LindÉn, K., et al.Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinasesMol. Pharmacol.59(5)1181-1186(2001) 4.Knoop, V.When you can’t trust the DNA: RNA editing changes transcript sequencesCell. Mol. Life Sci.68(4)567-586(2011)