Ulodesine is a purine nucleoside phosphorylase (PNP) inhibitor. Ulodesine inhibits PNP with IC50 value of 2.293 nM/L. Ulodesine can be used for the research of hyporucicemia[1][2].
Ulodesine (i.v.) potently inhibits PNP with IC50 value of 2.293 nM/L[1].
Ulodesine (i.v.) eliminates uric acid accumulations in blood of the mouse model[1].
[1]. Xujuan YANG, et al. Establishment of a novel hyperuricemiaanimal model using mice and assessment ofhyporuricemia action of PNP inhibitor Ulodesine.
[2]. Cesar Diaz-TornÉ, et al. New medications in development for the treatment of hyperuricemia of gout. Curr Opin Rheumatol. 2015 Mar;27(2):164-9.