TrxR-IN-5 (compound 4f) is a potent TrxR (thioredoxin reductase) inhibitor, with an IC50 of 0.16 μM. TrxR-IN-5 increases the levels of ROS, thus leading to potent antiproliferative effects. TrxR-IN-5 exhibits prominent anticacer and anti-metastasis effects[1].
TrxR-IN-5 (compound 4f) (MDA-MB-231 xenograft in BALB/c nude mice, 0-25 mg/kg, IP, once) shows strong inhibition potency toward solid tumors of breast cancer in vivo[1].
[1]. Meng C, et al. Efficacy of novel methylenecyclohexenone derivatives as TrxR inhibitors in suppressing the proliferation and metastasis of human cancer cells. Bioorg Chem. 2020 Dec;105:104360.