Thymine-d4 is intended for use as an internal standard for the quantification of thymine by GC- or LC-MS. Thymine is a pyrimidine base.1 It forms complementary base pairs with the purine adenine in DNA.1 Thymine is produced by the catabolism of thymidine via thymidine phosphorylase.2 It is replaced with uracil in RNA.3
1.Ghannam, J.Y., Wang, J., and Jan, A.Biochemistry, DNA Structure1-5(2021) 2.Brown, N.S., and Bicknell, R.Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesisBiochem. J.334(Pt 1)1-8(1998) 3.Banoub, J.H., Newton, R.P., Esmans, E., et al.Recent developments in mass spectrometry for the characterization of nucleosides, nucleotides, oligonucleotides, and nucleic acidsChem. Rev.105(5)1869-1915(2005)