Thalidomide 4'-oxyacetamide-alkylC4-amine

目录号: GC50464纯度: >98.00%
Thalidomide 4'-oxyetamide-alkylC4-amine 是一种合成的 E3 连接酶配体-接头偶联物,包含基于 Thalidomide 的 cereblon 配体和接头,可用于 PROTAC 的合成。

Thalidomide 4'-oxyacetamide-alkylC4-amine
Cas No.: 2245697-86-1
规格价格库存数量操作
25mg¥1,080.00现货
1
50mg¥1,782.00现货
1
100mg¥2,934.00现货
1

文献被引

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    641, 529–536 (2025)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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产品描述 Description

Functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a short alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D. This product has been recently renamed. The previous name for this product was Thalidomide - linker 3 PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Winter et al (2015) Drug development. Phthalimide conjugation as a strategy for in vivo target protein degradation. Science 348 1376 PMID:25999370 |Salami et al (2017) Waste disposal-An attractive strategy for cancer therapy. Science 355 1163 PMID:28302825

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
2245697-86-1
SMILES
NCCCCNC(COC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O.Cl
分子式
C19H22N4O6.HCl
分子量
438.86 g/mol
溶解性
Soluble in DMSO
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至 37°C,然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备 RT,或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol