GlpBio

Terlipressin diacetate

目录号: GC70580纯度: >99.00%
Terlipressin diacetate是一种具有强效血管活性特性的加压素类似物。
Terlipressin diacetate
Cas No.: 1884420-36-3
规格价格库存数量操作
1 mg¥180.00现货
1
5 mg¥450.00现货
1
10 mg¥612.00现货
1
25 mg¥1,125.00现货
1
50 mg¥1,494.00现货
1
100 mg¥2,385.00现货
1
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文献被引

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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

Terlipressin diacetate is a vasopressin analogue with potent vasoactive properties. Terlipressin diacetate is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin diacetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin diacetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research.

Terlipressin diacetate (25 nM; 24-72 hours; IEC-6 cells) treatment significantly improves cell viability, proliferation and apoptosis in IEC-6 cells[1].
Terlipressin diacetate inhibits the secretion of TNF-α and 15-F2t-isoprostane from IEC-6 cells following oxygen and glucose deprivation/re-oxygenation (OGD/R). Terlipressin diacetate administration following OGD attenuates OGD/R-induced cell damage via the PI3K signaling pathway[1].

Using a mouse nonlethal hepatic ischemia-reperfusion (IR) model, Terlipressin diacetate administration significantly ameliorates IR-induced liver apoptosis, necrosis and inflammation[3].

References:
[1]. Zi-Meng Liu, et al. Terlipressin Protects Intestinal Epithelial Cells Against Oxygen-Glucose Deprivation/Re-Oxygenation Injury via the Phosphatidylinositol 3-kinase Pathway. Exp Ther Med. 2017 Jul;14(1):260-266.
[2]. Yeun Tarl Fresner Ng Jao, et al. Refractory Torsade De Pointes Induced by Terlipressin (Glypressin). Int J Cardiol. 2016 Nov 1;222:135-140.
[3]. Xiqiang Liu, et al. Signaling Through Hepatocyte Vasopressin Receptor 1 Protects Mouse Liver From Ischemia-Reperfusion Injury. Oncotarget. 2016 Oct 25;7(43):69276-69290.
[4]. Xinmiao Zhou, et al. Terlipressin for the Treatment of Acute Variceal Bleeding: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicine (Baltimore). 2018 Nov;97(48):e13437.
[5]. Alastair O'Brien, et al. Terlipressin for Norepinephrine-Resistant Septic Shock. Lancet. 2002 Apr 6;359(9313):1209-10.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
1884420-36-3
分子式
C56H82N16O19S2
分子量
1347.48 g/mol
溶解性
H<sub>2</sub>O : 100 mg/mL (74.21 mM; Need ultrasonic)DMSO : 50 mg/mL (37.11 mM; Need ultrasonicHygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
保存条件
Stored under nitrogen, away from moisture
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol