GlpBio

TED-347

目录号: GC39540纯度: >98.50%

TED-347 is a potent, irreversible, covalent and allosteric inhibitor of the TEAD-Yap protein-protein interaction. TED-347 inhibits TEAD4⋅Yap1 protein-protein interaction with an apparent EC50 of 5.9 μM.

TED-347
Cas No.: 2378626-29-8
规格价格库存数量操作
1mg¥700.00现货
1
5mg¥910.00现货
1
10mg¥1,365.00现货
1
25mg¥2,576.00现货
1
50mg¥3,675.00现货
1
10mM (in 1mL DMSO)¥770.00现货
1
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文献被引

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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    31, 1291–1307 (2021)

产品描述 Description

TED-347 is a potent, irreversible, covalent and allosteric inhibitor of the TEAD-Yap protein-protein interaction. TED-347 inhibits TEAD4⋅Yap1 protein-protein interaction with an apparent EC50 of 5.9 μM.

TED-347 is found to inhibit the protein-protein interaction in a time-dependent manner. TED-347 is shown to functionally disrupt the TEAD·Yap1 interaction in cells and to reduce the viability of patient-derived glioblastoma cell lines.[1]

[1] Khuchtumur Bum-Erdene, et al. Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13.

产品文档 Product Documents

Purity:>98.50%

化学性质Chemical Properties

CAS 号
2378626-29-8
SMILES
O=C(C1=CC=CC=C1NC2=CC=CC(C(F)(F)F)=C2)CCl
分子式
C15H11ClF3NO
分子量
313.7 g/mol
溶解性
DMSO: 250 mg/mL (796.94 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol