GlpBio

SZ1676

目录号: GC31228纯度: >98%
COASDSData Sheet
SZ1676是SZ1677的衍生物，SZ1677是一种神经肌肉阻滞剂。
SZ1676
Cas No.: 159325-23-2
规格价格库存数量操作
1mg¥2,678.00现货
1
5mg¥5,355.00现货
1
10mg¥9,104.00现货
1
20mg¥16,065.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

SZ1676 is a derivative of SZ1677, which is a neuromuscular blocking agent.

SZ1676 is the 3-acetoxy derivative[1]. The neuromuscular (NM) effects of SZ1676 and SZ1677 are compared in beagle dogs. SZ1677 (ED90=19.2±2.6 μg/kg) is 1.86 times more potent than SZ1676 (ED90=35.8±2.5 μg/kg)[2].

[1]. B?azewicz A, et al. Application of high-performance liquid chromatography with amperometric and coulometric detection to the analysis of SZ1677, a new neuromuscular blocking agent, and its two derivatives. J Chromatogr A. 2008 Sep 12;1204(1):114-8. [2]. Francis F. Foldes, et al. Comparison of the Neuromuscular Effects of SZ1676, SZ1677 and Vecuronium in Beagle Dogs. Muscle Relaxants pp 379-379.

实验参考方法 Experimental Reference Method

Animal experiment:

Dogs[2] Beagle dogs of about 10 kg body weight, anesthetized with isofurane are intubated and mechanically ventilated with O2, One fore-leg is fixed above the elbow and the wrist and the ulnar nerve is stimulated at the elbow, percutaneously,with supramaximal electrical impulses of 0.2 ms duration at 0.1 or 0.4 Hz.The force of flxion of the paw (P) is quantitated and contiuously recorded, At first the ED50, ED90 and ED95 of the 2 muscle relaxants (MR) are determined.Thirty min after maximal spontaneous recovery of P,the calculated 2×ED90 is injected and the time course ol the NM and circulatory effects are determined.

References:

[1]. Błazewicz A, et al. Application of high-performance liquid chromatography with amperometric and coulometric detection to the analysis of SZ1677, a new neuromuscular blocking agent, and its two derivatives. J Chromatogr A. 2008 Sep 12;1204(1):114-8.
[2]. Francis F. Foldes, et al. Comparison of the Neuromuscular Effects of SZ1676, SZ1677 and Vecuronium in Beagle Dogs. Muscle Relaxants pp 379-379.

产品文档 Product Documents

Purity:>98%
COASDSData Sheet

化学性质Chemical Properties

CAS 号
159325-23-2
SMILES
C[C@@]12[C@](C[C@H]([N+]3(CCCC3)CC=C)[C@@H]2OC(C)=O)([H])[C@@]4([H])[C@]([C@@]5([C@@](C[C@H](OC(C)=O)[C@@H](N6CCC7(OCCO7)CC6)C5)([H])CC4)C)([H])CC1.[Br-]
分子式
C37H59BrN2O6
分子量
707.78 g/mol
溶解性
Soluble in DMSO
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol