Death-associated protein kinase (DAPK) is a serine/threonine protein kinase implicated in diverse programmed cell death pathways. DAPK is a promising target protein for the treatment of ischemic diseases. TC-DAPK 6 is an oxazalone compound that acts as a potent, ATP-competitive, and highly selective death-associated protein kinase (DAPK) inhibitor (IC50 = 69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 μM ATP); while exhibiting much reduced or no activity against a panel of 48 other kinases even at concentrations as high as 10 μM.
TC-DAPK 6
目录号: GC13950纯度: >98%同义词: DAPK inhibitor
TC-DAPK 6 是一种有效的、ATP 竞争性的、高度选择性的 DAPK 抑制剂（对 DAPK1 和 DAPK3 的 IC50 分别为 69 和 225 nM，ATP 浓度为 10 μM）。
Cas No.: 315694-89-4
| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 1mg | ¥134.00 | 现货 | 1 | |
| 5mg | ¥280.00 | 现货 | 1 | |
| 10mg | ¥455.00 | 现货 | 1 | |
| 25mg | ¥840.00 | 现货 | 1 | |
| 50mg | ¥1,190.00 | 现货 | 1 | |
| 100mg | ¥1,750.00 | 现货 | 1 | |
| 10mM (in 1mL DMSO) | ¥406.00 | 现货 | 1 |
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产品描述 Description
实验参考方法 Experimental Reference Method
Kinase experiment: | Kinase assay is performed using the Z’-LYTE kinase assay kit Ser/Thr 13 peptide. The standard reaction for compound screening contained 1 mM peptide substrate, 10 mM ATP, 50 mM HEPES (pH 7.4), 10 mM MgCl2, 0.01% Brij-35, and 0.5% DMSO. Human recombinant DAPK1 is used at a final concentration of 2.6 μg/mL, and recombinant DAPK3 is used at a final concentration 1.5 mg/mL. To test the enzyme selectively of the inhibitors (e.g., TC-DAPK 6), ProfilerPro kits are used in the protocol[1]. |
References: [1]. Okamoto M, et al. Identification of death-associated protein kinases inhibitors using structure-based virtual screening. J Med Chem. 2009 Nov 26;52(22):7323-7. |
产品文档 Product Documents
Purity:>98%
化学性质Chemical Properties
CAS 号
315694-89-4
同义词
DAPK inhibitor
化学名
(4E)-2-[(E)-2-phenylethenyl]-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5-one
SMILES
C1=CC=C(C=C1)C=CC2=NC(=CC3=CN=CC=C3)C(=O)O2
分子式
C17H12N2O2
分子量
276.29 g/mol
溶解性
Soluble in DMSO
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。
计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度
g/mol