PNU 100480 is an oxazolidinone antibiotic that is active against multidrug resistant tuberculosis.1 It inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid , rifampin , ethambutol , and streptomycin .1,2 It also inhibits the growth of P. insidiosum and P. aphanidermatum clinical isolates (MICs = 4-64 μg/ml).3 PNU 100480 (100 mg/kg per day) decreases the number of colony forming units (CFU) in the lung in a mouse model of systemic nonreplicating M. tuberculosis infection.2
1.Alffenaar, J.W., van der Laan, T., Simons, S., et al.Susceptibility of clinical Mycobacterium tuberculosis isolates to a potentially less toxic derivate of linezolid, PNU-100480Antimicrob. Agents Chemother.55(3)1287-1289(2011) 2.Zhang, M., Sala, C., Dhar, N., et al.In vitro and in vivo activities of three oxazolidinones against nonreplicating Mycobacterium tuberculosisAntimicrob. Agents Chemother.58(6)3217-3223(2014) 3.Loreto, E.S., Tondolo, J.S.M., Oliveira, D.C., et al.In vitro activities of miltefosine and antibacterial agents from the macrolide, oxazolidinone, and pleuromutilin classes against Pythium insidiosum and Pythium aphanidermatumAntimicrob. Agents Chemother.62(3)e01678-01617(2018)