st-Ht31 (5 µM; 2 h) ammonium enhances cholesterol/phospholipid efflux in BHK cells and RAW macrophages[1].
st-Ht31 (10µM; 24 h) ammonium reverses foam cell formation and restores metabolic health of macrophage[1].
st-Ht31 (20 µM; 20 min) ammonium abolishes the cAMP inhibition of PMA-induced ERK1/2 activation n HEK293T cells[2].
References:
[1]. Ma L, et al. Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1. J Biol Chem. 2011 Feb 4;286(5):3370-8.
[2]. Rahamim Ben-Navi L, et al. A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa. Sci Rep. 2016 Nov 30;6:37922.