Sophoraflavanone G is a flavonoid that has been found in S. flavescens and has diverse biological activities.1,2,3,4 It is active against 21 strains of methicillin-resistant S. aureus (MRSA; MICs = 3.13-6.25 ?g/ml) and inhibits the activities of α-glucosidase and β-amylase (Kis = 5.6 and 30.6 ?M, respectively).1,2 Sophoraflavanone G is cytotoxic to HL-60 and HepG2 cancer cells (IC50s = 12.5 and 13.3 ?M, respectively) and induces apoptosis in HL-60 cells when used at concentrations of 10 or 25 ?M.3 It reduces LPS-induced production of prostaglandin E2 in RAW 264.7 cells when used at concentrations ranging from 1 to 50 ?M.4 Sophoraflavanone G (250 mg/kg) inhibits carrageenan-induced paw edema in rats.
1.Sato, M., Tsuchiya, H., Takase, I., et al.Antibacterial activity of flavanone isolated from Sophora exigua against methicillin-resistant Staphylococcus aureus and its combination with antibioticsPhytother. Res.9(7)509-512(1995) 2.Kim, J.H., Ryu, Y.B., Kang, N.S., et al.Glycosidase inhibitory flavonoids from Sophora flavescensBiol. Pharm. Bull.29(2)302-305(2006) 3.Ko, W.G., Kang, T.H., Kim, N.Y., et al.Lavandulylfavonoids: A new class of in vitro apoptogenic agents from Sophora favescensToxicol. In Vitro14(5)429-433(2000) 4.Kim, D.W., Chi, Y.S., Son, K.H., et al.Effects of sophoraflavanone G, a prenylated flavonoid from Sophora flavescens, on cyclooxygenase-2 and in vivo inflammatory responseArch. Pharm. Res.25(3)329-335(2002)