Sodium laureth sulfate (Sodium lauryl polyoxyethylene ether sulfate)
(Synonyms: 月桂醇聚氧乙烯醚硫酸酯钠盐,Sodium lauryl polyoxyethylene ether sulfate) 目录号 : GC30005
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Sodium laureth sulfate (Sodium lauryl polyoxyethylene ether sulfate)是一种阴离子表面活性剂，具有优良的去污、乳化、分散、润湿和发泡性能。
Cas No.:9004-82-4
Sample solution is provided at 25 µL, 10mM.
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Sodium laureth sulfate (Sodium lauryl polyoxyethylene ether sulfate) is an anionic surfactant with excellent properties in detergency, emulsification, dispersion, wetting, and foaming[1]. Sodium laureth sulfate effectively reduces the surface tension of liquids, separates dirt molecules, and produces abundant foam to enhance cleaning efficacy[2].
In vitro, Sodium laureth sulfate (0.01–0.50mg/mL) combined with plasma‑activated water and applied to Saccharomyces cerevisiae cells for 20–30min can cause severe disruption of cell membrane integrity, Sodium laureth sulfate increased lipid peroxidation, accumulation of intracellular reactive oxygen species, and abnormal mitochondrial membrane potential[3].
In vivo, topical application of Sodium laureth sulfate (50mg/kg) to guinea pig skin for 7–14 days, Sodium laureth sulfate can significantly elevate the activities of multiple enzymes, including acid phosphatase, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, β‑glucuronidase, lactate dehydrogenase, and malate dehydrogenase, while also markedly increasing the levels of amino nitrogen and sulfhydryl groups in the skin[4].
References:
[1] Bhattacharya R, Chatterjee A, Chatterjee S, et al. Acute toxicity and sublethal effects of sodium laureth sulfate on oxidative stress enzymes in benthic oligochaete worm, Tubifex tubifex. Comp Biochem Physiol C Toxicol Pharmacol. 2021 May;243:108998.
[2] Symanzik C, Weinert P, Babić Ž, et al. Skin Toxicity of Selected Hair Cosmetic Ingredients: A Review Focusing on Hairdressers. Int J Environ Res Public Health. 2022 Jun 21;19(13):7588.
[3] Liu X, Li Y, Zhang R, et al. Inactivation effects and mechanisms of plasma-activated water combined with sodium laureth sulfate (SLES) against Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2021 Apr;105(7):2855-2865.
[4] Mathur AK, Agarwal C, Singh A, et al. Effect of sodium lauryl sulphate and nickel alone and in combination on the skin of guinea pigs. Toxicol Lett. 1988 Sep;42(3):249-56.
Sodium laureth sulfate (Sodium lauryl polyoxyethylene ether sulfate)是一种阴离子表面活性剂，具有优良的去污、乳化、分散、润湿和发泡性能[1]。Sodium laureth sulfate通过降低液体表面张力，有效分离污垢分子，并形成丰富泡沫以增强清洁效果[2]。
在体外，Sodium laureth sulfate(0.01–0.50mg/mL)联合等离子体活化水处理酿酒酵母细胞20–30min，Sodium laureth sulfate可导致细胞膜完整性严重破坏、膜脂质过氧化水平升高以及细胞内活性氧积累，同时引起线粒体膜电位异常[3]。
在体内，Sodium laureth sulfate(50mg/kg)局部涂抹处理豚鼠皮肤7–14天，Sodium laureth sulfate可导致酸性磷酸酶、碱性磷酸酶、天冬氨酸氨基转移酶、丙氨酸氨基转移酶、β-葡萄糖醛酸酶、乳酸脱氢酶和苹果酸脱氢酶等多种酶活性显著升高，同时皮肤中氨基氮和巯基含量也明显增加[4]。
| Cell experiment [1]: | |
Cell lines | Saccharomyces cerevisiae (yeast strain ATCC9763) |
Preparation Method | S. cerevisiae cells were cultured in yeast extract-peptone-dextrose (YPD) medium at 30°C with shaking (120rpm) until mid-log phase. Cells were harvested, washed, and resuspended in sterile saline (0.85% NaCl). Cells were treated with plasma-activated water (PAW) combined with Sodium laureth sulfate at concentrations of 0.01–0.50mg/mL for 5–20min. |
Reaction Conditions | 0.01–0.50mg/mL; 5–20min |
Applications | The combined treatment of PAW and Sodium laureth sulfate synergistically inactivated S. cerevisiae, reducing the population from 6.95 log10CFU/mL to undetectable levels. Sodium laureth sulfate enhanced PAW-induced membrane damage, leading to leakage of intracellular nucleic acids and proteins. |
| Animal experiment [2]: | |
Animal models | Albino guinea pigs |
Preparation Method | Guinea pigs were treated topically with Sodium lauryl sulphate at 50mg/kg alone or in combination with Sodium laureth sulfate (50mg/kg) for 7 and 14 days. The treated skin was homogenized in sucrose solution, and enzyme activities and biochemical parameters were analyzed. |
Dosage form | 50mg/kg; topical application; daily for 7–14 days. |
Applications | Sodium laureth sulfate treatment significantly increased the activities of lysosomal enzymes (acid phosphatase, β-glucuronidase), cytoplasmic enzymes (lactic dehydrogenase, malic dehydrogenase), and amino acid metabolism enzymes (aspartate aminotransferase, alanine aminotransferase). Sodium laureth sulfate also elevated skin amino nitrogen and sulphydryl group contents. These alterations were more pronounced when Sodium laureth sulfate was combined with nickel, indicating synergistic dermal toxicity. The study suggests that Sodium laureth sulfate induces skin irritation through membrane damage, protein denaturation, and inflammatory responses, highlighting risks for industrial workers exposed to Sodium laureth sulfate and nickel. |
References: | |
| Cas No. | 9004-82-4 | SDF | |
| 别名 | 月桂醇聚氧乙烯醚硫酸酯钠盐,Sodium lauryl polyoxyethylene ether sulfate | ||
| Canonical SMILES | CCCCCCCCCCCCOCCOS(=O)(O)=O.[n].[Na+] | ||
| 分子式 | (C2H4O)n C12H26O4S . Na | 分子量 | |
| 溶解度 | Water : ≥ 31 mg/mL | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
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