Sodium laureth sulfate (Sodium lauryl polyoxyethylene ether sulfate) is an anionic surfactant with excellent properties in detergency, emulsification, dispersion, wetting, and foaming[1]. Sodium laureth sulfate effectively reduces the surface tension of liquids, separates dirt molecules, and produces abundant foam to enhance cleaning efficacy[2].
In vitro, Sodium laureth sulfate (0.01–0.50mg/mL) combined with plasma‑activated water and applied to Saccharomyces cerevisiae cells for 20–30min can cause severe disruption of cell membrane integrity, Sodium laureth sulfate increased lipid peroxidation, accumulation of intracellular reactive oxygen species, and abnormal mitochondrial membrane potential[3].
In vivo, topical application of Sodium laureth sulfate (50mg/kg) to guinea pig skin for 7–14 days, Sodium laureth sulfate can significantly elevate the activities of multiple enzymes, including acid phosphatase, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, β‑glucuronidase, lactate dehydrogenase, and malate dehydrogenase, while also markedly increasing the levels of amino nitrogen and sulfhydryl groups in the skin[4].
References:
[1] Bhattacharya R, Chatterjee A, Chatterjee S, et al. Acute toxicity and sublethal effects of sodium laureth sulfate on oxidative stress enzymes in benthic oligochaete worm, Tubifex tubifex. Comp Biochem Physiol C Toxicol Pharmacol. 2021 May;243:108998.
[2] Symanzik C, Weinert P, Babić Ž, et al. Skin Toxicity of Selected Hair Cosmetic Ingredients: A Review Focusing on Hairdressers. Int J Environ Res Public Health. 2022 Jun 21;19(13):7588.
[3] Liu X, Li Y, Zhang R, et al. Inactivation effects and mechanisms of plasma-activated water combined with sodium laureth sulfate (SLES) against Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2021 Apr;105(7):2855-2865.
[4] Mathur AK, Agarwal C, Singh A, et al. Effect of sodium lauryl sulphate and nickel alone and in combination on the skin of guinea pigs. Toxicol Lett. 1988 Sep;42(3):249-56.
Sodium laureth sulfate (Sodium lauryl polyoxyethylene ether sulfate)是一种阴离子表面活性剂，具有优良的去污、乳化、分散、润湿和发泡性能[1]。Sodium laureth sulfate通过降低液体表面张力，有效分离污垢分子，并形成丰富泡沫以增强清洁效果[2]。
在体外，Sodium laureth sulfate(0.01–0.50mg/mL)联合等离子体活化水处理酿酒酵母细胞20–30min，Sodium laureth sulfate可导致细胞膜完整性严重破坏、膜脂质过氧化水平升高以及细胞内活性氧积累，同时引起线粒体膜电位异常[3]。
在体内，Sodium laureth sulfate(50mg/kg)局部涂抹处理豚鼠皮肤7–14天，Sodium laureth sulfate可导致酸性磷酸酶、碱性磷酸酶、天冬氨酸氨基转移酶、丙氨酸氨基转移酶、β-葡萄糖醛酸酶、乳酸脱氢酶和苹果酸脱氢酶等多种酶活性显著升高，同时皮肤中氨基氮和巯基含量也明显增加[4]。