Kaempferol 3-neohesperidoside is a flavonoid that has been found in D. calycinum and has antioxidant and antidiabetic activities.1,2,3,4 It scavenges DPPH radicals in a cell-free assay (IC50 = 79.6 ?g/ml).1 Kaempferol 3-neohesperidoside (1 and 100 nM) increases glucose uptake in isolated rat soleus muscle.2 It also increases glycogen synthesis in isolated rat soleus muscle, an effect that can be blocked by the PI3K inhibitor wortmannin and the MEK inhibitor PD 98059 , when used at a concentration of 1 ?M.3 Kaempferol 3-neohesperidoside (100 mg/kg) reduces serum glucose levels in a rat model of diabetes induced by alloxan .4
1.Gamez, E.J.C., Luyengi, L., Lee, S.K., et al.Antioxidant flavonoid glycosides from Daphniphyllum calycinumJ. Nat. Prod.61(5)706-708(1998) 2.Zanatta, L., Rosso, ?., Folador, P., et al.Insulinomimetic effect of kaempferol 3-neohesperidoside on the rat soleus muscleJ. Nat. Prod.71(4)532-535(2008) 3.Cazarolli, L.H., Folador, P., Pizzolatti, M.G., et al.Signaling pathways of kaempferol-3-neohesperidoside in glycogen synthesis in rat soleus muscleBiochimie91(7)843-849(2009) 4.Cazarolli, L.H., Zanatta, L., Jorge, A.P., et al.Follow-up studies on glycosylated flavonoids and their complexes with vanadium: Their anti-hyperglycemic potential role in diabetesChem. Biol. Interact.163(3)177-191(2006)