SN-001 is a STING inhibitor with an IC50 of 3.82 μM[1].
SN-001 targets the cyclic dinucleotide binding pocket of human STING[1].
SN-001 (5-20 μM; 6 h) significantly impairs the induction of Ifnb mRNA, in a dose-dependent manner in L929 cells[1].
SN-001 (10 μM; 3 h) inhibits cytosolic DNA-triggered STING signaling[1].
Western Blot Analysis[1]
| Cell Line: | L929 cells |
| Concentration: | 10 μM |
| Incubation Time: | 3 h |
| Result: | Decreased cytosolic DNA-induced phosphorylation of STING, TBK1, IRF3, IκBα, and p65, as well as nuclear translocation of IRF3 and p65. |
[1]. Hong Z, et al. STING inhibitors target the cyclic dinucleotide binding pocket. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2105465118.