SKA-111 is a selective activator of potassium phannel KCa 3.1 , evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell. SKA-111 is capable of improving Bradykinin -induced coronary dilations in the isolated rat heart and can be used for cardiovascular disease research.
SKA-111 (1 μM, 5 min) evokes KCa 3.1 membrane hyperpolarization in porcine endothelial cell[1].
SKA-111 (1 μM, 5 min) induces significantly augmented the Bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in large porcine coronary arteries (PCA) [1].
SKA-111 (1 μM for cardiac perfusion) improves Bradykinin -induced coronary dilations in the isolated rat heart[1].
References:
[1]. Oliván-Viguera A, et.al. Vascular Reactivity Profile of Novel KCa 3.1-Selective Positive-Gating Modulators in the Coronary Vascular Bed. Basic Clin Pharmacol Toxicol. 2016 Aug;119(2):184-92.