SJPYT-195 is a cytotoxic GSPT1 degrader and can be used for PROTAC synthesis[1].
SJPYT-195 (24 h) potently and efficaciously reduces endogenous PXR (pregnane X receptor) protein in the colorectal SNU-C4 cell line (SNU-C4 3xFLAG-PXR KI cells), with a half maximal degradation concentration (DC50) of 310 ± 130 nM and maximum degradation efficacy (DMax) of 85 ± 1%[1].
SJPYT-195 reduces PXR protein through the degradation of GSPT1[1].
[1]. Huber A D, et al. SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1. ACS Medicinal Chemistry Letters, 2022.