关于 "peptides" 的结果28 个结果

RGD (Arg-Gly-Asp) Peptides是一种三肽，能够与整合素结合，有效引起细胞黏着，定位某种特定细胞系并产生特定的细胞反应。

MPG peptides, Pβ 是一种两亲性肽，由三个结构域组成。

Cancer Biology Peptides

Reagent for activating the carboxylic group, synthesis of amides 1,2; Esters 3; Peptides 4

The polymyxins are cationic peptides originally isolated from B.

Usually used to modify therapeutic proteins and peptides to increase their solubility and lower their toxicity

The amino-protecting group Dde is orthogonal to both Fmoc and Boc protection and finds increasing application in the synthesis of modified peptides assembled by Fmoc-tBu solid-phase methodologies. Dde can be cleaved by 2 % hydrazine in DMF.

Chromogen developed as a safe substitute for conventional benzidine type reagents. For detection of N-Boc-protected amino acids and peptides by TLC. Substrate for peroxidases as horse radish peroxidase.

Peptides containing 2-aminopimelic acid (Apm) inhibit diaminopimelic acid biosynthesis in bacteria.

FITC-LC-Antp Homeobox (43-58) amide can be used to translocate covalently attached peptides through biological membranes. The fluorescence label is useful for fluorescence-activated cell sorting (FACS) analysis and fluorescence microscope studies.

Derivative for the Fmoc-SPPS of backbone-protected peptides. Introduction of Dmb at appropriate positions prevents aggregation of the growing peptide chain. Conroy et al. could stabilize the aspartimide-prone Asp(OAll or ODmab)-Ala motif by incorporating DmbAla. Please see also our Dmb-dipeptides.

Derivative for the Fmoc-SPPS of backbone-protected peptides. Introduction of Dmb at appropriate positions prevents aggregation and aspartimide formation. Please see also our Dmb-dipeptides.

Derivative for the Fmoc-SPPS of backbone-protected peptides. Introduction of Dmb at appropriate positions prevents aggregation of the growing peptide chain. Please see also our Dmb-dipeptides.

Incorporation of HmbGly during Fmoc-SPPS prevents the aggregation of the growing peptide. Hmb is removed during the final TFA cleavage, which can be prevented by O-acetylation. Please see also our Hmb- and Dmb-dipeptides.

Peptides containing m-iodotyrosine and tryptophan can be cyclized via Pd-catalyzed C-H activation.

Resin for Fmoc-synthesis of C-terminally amidated peptides. Peptides are cleaved by trifluoroacetic acid. Scavengers may be required.

Introduction of the Dmb-moiety disrupts aggregated sequences during Fmoc-SPPS as efficiently as a pseudoproline residue. Dmb dipeptides couple smoothly, as, contrary to Hmb dipeptides, they cannot form oxazepinones. Dmb is removed during the final TFA cleavage in the presence of scavengers.

Fmoc-Ebes, short PEG spacer, which can be incorporated into peptides during SPPS.

Nω-Methylation is a widespread post-translational modification of Arg-containing proteins. Arg(Me) can be conveniently introduced during the Fmoc-SPPS of model peptides using this derivative.

Mtt carboxamide protection is superior to Trt when synthesizing peptides containing an N-terminal Asn, as the latter is cleaved only sluggishly in this position.

Dmab can be removed with 2% hydrazine in DMF generating an indazole which allows the UV-spectrophotometrical monitoring of the cleavage. Conroy et al. used this Asp derivative for the solid-phase synthesis of N-linked glycopeptides. As Dmab represents an unhindered p-substituted Z-derivative, Asp(Dmab)-containing peptides are prone to base-catalyzed aspartimide formation.

Aspartimide formation of the highly base-labile Asp-Gly motif during Fmoc-SPPS may be completely suppressed by coupling this Hmb-protected dipeptide derivative. Additionally, Hmb prevents aggregation of the growing peptide chain as efficiently as the incorporation of a pseudoproline moiety. O-Acylation renders the Hmb moiety acid-stable facilitating the purification of peptides prone to form aggregates. The acyl group can be removed with hydrazine hydrate in DMF (cf. Quibell).

Derivative for synthesizing β-Asp peptides. Use of OMpe in place of OtBu significantly reduces aspartimide formation, a notorious base-catalyzed side-chain reaction observed with both linear and branched Asp-containing peptides during Fmoc-SPPS.

Stabilizes the PPII helix in Pro-rich short peptides, though less efficiently than the trans isomer. Oligomers of flp were studied by Horng and Raines.