关于 "Cytoskeleton & Motor Proteins" 的结果165+ 个结果

Abl protein tyrosine kinase substrate是一种生物活性肽。

Protein kinase G inhibitor-1 (Compound 270) 是一种分枝杆菌 protein kinase G 抑制剂，IC50 为 0.9 μM。Protein kinase G inhibitor-1 可用于分枝杆菌感染研究。

N-terminally biotin-labeled Aβ42.

RKKRRQRRR, a nine amino acid motif within the HIV-1 tat protein transduction domain (PTD), suffices for the transduction of heterologous proteins through the plasma membrane.

Butyrylcholinesterase (BChE) is a serine hydrolase that is structurally similar to acetylcholinesterase (AChE), but differs in substrate specificities and inhibitor sensitivities. BChE can, unlike AChE, efficiently hydrolyze larger esters of choline

Microtubule-associated protein tau (26-44) 是一个合成肽链，具有连接到谷氨酰胺的胺基和与赖氨酸连接的羧基。

C-Reactive Protein (CRP) 174-185 是 C-反应蛋白的 174-185 片段。C-Reactive Protein 可作为炎症的标记，是心血管风险的标志物，可能促进动脉粥样硬化形成。

Acyl Carrier Protein (ACP) (65-74) 是一种有活性的酰基载体蛋白 ACP 片段。

PD-1蛋白是T细胞上的抑制性受体，通过与CD274/PDCD1L1和CD273/PDCD1LG2结合来维持免疫耐受。

PDE3A 蛋白是一种环核苷酸磷酸二酯酶，靶向 cAMP、cGMP 和 cUMP，这些在多种生理过程中至关重要。在 E2/17β-雌二醇诱导的促凋亡途径中，E2 稳定 PDE3A/SLFN12 复合物，导致 SLFN12 去磷酸化并激活其促凋亡核糖核酸酶活性。该途径与 E2 浓度高的组织有关，可能有助于胎盘重塑等过程。PDE3A 蛋白, Human (sf9, His-GST) 是重组的 PDE3A 蛋白，由 Sf9 insect cells 表达，带有 N-His, N-GST 标签。

T-PA 蛋白通过水解单个 Arg-Val 键将无活性的纤溶酶原转化为活性纤溶酶。这种转化调节纤溶酶介导的蛋白水解，并参与组织重塑、降解和细胞迁移。

骨形态发生蛋白 4 (BMP-4) 是一种多效性配体蛋白，属于 TGFβ 家族，参与血管系统循环，可以激活血管细胞上的受体。BMP-4 结合 I 型受体 (ALK-2/-3/-6) 和 II 型受体 (BMPR2, ACVR2A)，通过其促炎和促动脉粥样硬化作用增加斑块形成，促进氧化应激、内皮功能障碍和成骨分化。

PF-AKT400（AKT 蛋白激酶抑制剂）是一种广泛选择性、强效、ATP 竞争性 Akt 抑制剂，对 PKBα 的选择性高出 900 倍； (IC50=0.5 nM) 比 PKA (IC50=450 nM)。

介绍： &&活力定义：(TPI) One unit will convert 1.0 μmole of D-glyceraldehyde 3-phosphate to dihydroxyacetone phosphate per min at pH 7.6 at 25 °C. (α-GDH) One unit will convert 1.0 μmole of dihydroxyacetone phosphate to α-glycerophosphate per min at pH 7.4 at 25 °C. GDH活力：75～200units/mg protein (biuret). TPI活力：750～2000 units/mg protein. &&性状：悬浮液

Phosphatidylcholine transfer protein inhibitor-2 (专利中的 Answer 41) 是磷脂酰胆碱转移蛋白抑制剂。

Phosphatidylcholine transfer protein inhibitor-1 (专利中的 Answer 37) 是一种磷脂酰胆碱转移蛋白 (PC-TP) 抑制剂。Phosphatidylcholine transfer protein inhibitor-1 可用于肥胖等 PC-TP 相关的疾病研究。

与内盐相比，Aβ42 的盐酸盐在 pH 7.4 时更容易聚集。

Experiments using sub-peptides of Aβ42 revealed that the epitope identified by the antibody A8, as described by Ying and coworkers, lies within the 1-6 region of Aβ. The antibody displays high affinity for soluble Aβ42 oligomers in the molecular weight range of 16.5-25 kDa, and detected target antigen in brain sections from senescence-accelerated SAMP 8 mice.

Aβ 2-42 could be a biomarker for differentiating AD from other degenerative dementias, such as frontotemporal dementias (FTD). The peptide promotes phagocytosis by macrophages.

The N-terminally truncated Aβ42 may be formed in increased amounts as AD progresses. Aβ 3-42 is the precursor of the Pyr-peptide. (Pyr³)-Aβ 3-42 positive plaques are resistant to age-dependent degradation likely due to their high stability and propensity to aggregate.

Aβ 4-42 could be one of the earliest and most prominent Aβ species deposited in AD brain. Sequencing of amyloid plaque cores showed that 64% of the isolated Aβ had a phenylalanine at its N-terminus, and indeed, IP/MS experiments identified Aβ 4-42 as a major Aβ species in AD patients. Additionally, Aβ 4-42 was found to be a component of cotton wool plaques in familial AD patients with the V261I PS1 mutation. Aβ 4-42 was discovered as well in amyloid deposits from vascular dementia and familial Danish dementia patients. These observations indicate that Aβ 4-42 may contribute to the development of multiple CNS diseases.