关于 "Cytoskeleton & Motor Proteins" 的结果117+ 个结果

绿色荧光蛋白 (GFP) 是一种在蓝紫光范围内曝光时会发出绿色荧光的蛋白质，发现于包括 Aequorea victoria ，珊瑚，海葵，浮游动物，桡足类和文昌鱼在内的生物中。

IRAK-4 protein kinase inhibitor 2 is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM.

Target Protein-binding moiety 13 (PROTAC FKBP12-binding moiety 1) 是 FKBP (SLF) 的合成配体。目标蛋白结合部分 13（PROTAC FKBP12 结合部分 1）可用于 PROTAC 的合成。

Target Protein-binding moiety 8 (N-Deshydroxyethyl BMS-354825) 是 Dasatinib 的代谢物，Dasatinib 是一种多激酶抑制剂，可有效抑制 Bcr-Abl、Src 家族和血小板衍生的生长因子受体激酶。

Target Protein-binding moiety 6 是一种与 BRD9 结合的化合物，用于抑制 BRD9 的活性，基于 PROTAC。

CSH-103, ADAQHATPPKKKRKVEDPKDF, based on the simian virus 40 large T antigen sequence, is a specific substrate for p34 cdc2 protein kinase (Km= 0.07 mM). It is not phosphorylated by other kinases (casein kinase I/II, cAMP-dependent protein kinase, glycogen synthase kinase 3, phosphorylase b kinase, protein kinase C, calmodulin and kinase II).

Amyloid β-protein (10-35), YEVHHQKLVFFAEDVGSNKGAIIGLM, was used as a truncated peptide model for the full-length amyloid β-proteins (1-40) and (1-42) in high-resolution structural studies. In contrast to the full-length amyloid β-proteins, amyloid β-protein (10-35) allowed the controlled and reproducible formation of homogeneous fibrils from aqueous solutions of defined pH, ionic strength and soluble peptide concentration necessary for high-resolution structural studies.

The N-terminal Aβ fragments Aβ1-14, Aβ1-15 (H-6368), and Aβ1-16 (H-2958) are elevated in cell media and in CSF in response to γ-secretase inhibitor treatment. The presence of these small peptides is consistent with a catabolic amyloid precursor protein cleavage pathway by β- followed by α-secretase. It has been shown that Aβ1-14, Aβ1-15, and Aβ1-16 increase dose-dependently in response to γ-secretase inhibitor treatment while Aβ1-42 levels are unchanged.

淀粉样蛋白 β-蛋白质 (1-37) 与阿尔茨海默病的简易精神状态检查 (MMSE) 评分中度相关。

Like Aβ (25-35) (H-1192), the Aβ fragment (1-38) destabilizes calcium homeostasis and renders human cortical neurones vulnerable to environmental insults.

Small quantities of Aβ37, 38 and 39 can be detected in CSF together with Aβ40, the most abundant Aβ homolog, Aβ42, and N-terminally truncated amyloid peptides. The relative amounts depend on the variant of Alzheimer's disease. The C-terminally truncated amyloid peptides are also found in amyloid plaques.

淀粉样蛋白 β-Protein (1-43) 比久负盛名的 Aβ1-42 更容易聚集并具有更高的毒性。

Precursor of the secreted amyloid β-protein (1-40) and (1-42). The identification of amyloid-β-protein (1-46) led to the identification of a zeta-cleavage site between the known γ- and ε-cleavage sites within the transmembrane domain of amyloid-β precursor protein (APP).

Self-assembling Aβ sequence.

Cleavage of APP by alpha- and gamma-secretase (i.e. the non-amyloidogenic pathway) yields p3 peptide, a mix of Aβ 17-40 and Aβ 17-42. p3 is a major constituent of diffuse plaques observed in AD brains and pre-amyloid plaques in people affected by Down syndrome.

FAEDVGSNKG.