关于 "TRP Channel" 的结果26+ 个结果
- Farnesyl Pyrophosphate ammoniumCAS: 116057-57-9
Farnesyl pyrophosphate ammonium salt 是一种 15 碳类异戊二烯，是甲羟戊酸 (MVA) 途径的代谢中间体。Farnesyl pyrophosphate ammonium salt 是一种 TRPM2 (TRP Channel) 激动剂，可激活 TRPM2 打开，使离子流入到细胞内。
- GFB-8438CAS: 2304549-73-1
GFB-8438 is a novel, potent, and subtype selective TRP channel subfamily C (TRPC) inhibitor that is equipotent against TRPC4 and TRPC5 with IC50 of 0.18 μM and 0.29 μM, and shows excellent selectivity against TRPC6, other TRP family members , NaV 1.5, as well as limited activity against the hERG channel.
- Bax channel blockerCAS: 335165-68-9
Bax 通道阻滞剂是 BAX（一种凋亡调节剂）的选择性变构抑制剂。 Bax 通道阻滞剂直接与 BAX 结合并变构抑制 BAX 活化。 Bax 通道阻滞剂具有研究由 BAX 依赖性细胞死亡介导的疾病的潜力。
- Sodium Channel inhibitor 2CAS: 653573-60-5
SodiumChannelinhibitor2是一个钠通道阻断剂，来自专利WO2004011439A2，化合物3c。
- Calcium channel-modulator-1CAS: 136941-70-3
Calciumchannel-modulator-1是钙离子通道(calciumchannel)调节剂，阻塞主动脉收缩的IC50值为0.8μM。
- Ca2+ channel agonist 1CAS: 1402821-24-2
Ca2+channelagonist1是一种N-型钙离子通道(N-typeCa2+channel)激动剂和Cdk2的抑制剂，EC50分别为14.23μM和3.34μM，对运动神经终端功能障碍有潜在疗效。
- Calcium Channel antagonist 2CAS: 874370-15-7
Calcium Channel antagonist 2 (化合物 154) 是一种 calcium channel 拮抗剂 (IC50=5-20 μM)，可用于 Ca2+ 通道介导的疾病，如疼痛和糖尿病等。
- Calcium Channel antagonist 3CAS: 687573-14-4
Calcium Channel antagonist 3 (compound 397)?是一种电压门控钙通道抑制剂，IC50?值为?5-20μM。
- Calcium Channel antagonist 4CAS: 687574-49-8
Calcium Channelantagonist 4 (compound 189)?是一种电压门控钙通道抑制剂，IC50?值为?5-20μM。
- K+ Channel inhibitor 1734CAS: 343240-54-0
Building block for synthesis of dihydropyrazolopyrimidine inhibitors of Kv1.5 (IKur). The ethylester analog of inhibitor 1734 is a modest inhibitor itself (IC50 value 1.1 μM for human Kv1.5), but exhibiting encouraging KV1.5 versus L-type calcium channel selectivity.
- Kv1.3 Channel blocker 42CAS: 2108780-57-8
Potassium channel blocker, selective in blocking the Kv1.3 current (IC50:
- KV2 channel inhibitor-1CAS: 689297-68-5
KV2 channel inhibitor-1 是一种选择性 KV2 通道抑制剂，对 KV2.1 和 KV2.2 的 IC50 分别为 0.2 μM 和 0.41 μM。 KV2 channel inhibitor-1 对 KV1.2 具有良好的选择性 (IC50>10 μM)。 KV2 channel inhibitor-1 比 NaV 通道和其他 KV 通道的选择性高 10 倍以上，并且在 CaV 通道上表现出弱活性。
- NaV1.2/1.6 channel blocker-1CAS: 1199944-04-1
NaV1.2/1.6 channel blocker-1 是一种有效的 NaV1.2/1.6 channel 阻滞剂，抑制 rNaV1.6 和 hNaV1.2 的 IC50 值分别为 9.8 和 24.4 μM。NaV1.2/1.6 channel blocker-1 可用于全身性癫痫的研究。
- Kv3, Channel Containing Protein 567-585
Kv3, Channel Containing Protein (567-585) 是Kv3.1b 通道蛋白的567-586 氨基酸肽。Kv3 channel protein 在含有pallidal 神经元的 PV 蛋白表达。
- N-type calcium channel blocker-1CAS: 241499-17-2
N-typecalciumchannelblocker-1是有口服活性的麻醉剂，可阻断N型钙离子通道(N-typecalciumchannels)，在IMR32试验中IC50值为0.7μM。
- H-Trp-Trp-Trp-OHCAS: 59005-82-2
Tritryptophan, WWW, a highly hydrophobic tripeptide used as a model in phase distribution studies.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC13930 | N-(p-amylcinnamoyl) Anthranilic Acid | 110683-10-8 | TRP Channel | ||
A TRP channel blocker and PLA2 inhibitor | |||||
| GC70353 | Farnesyl Pyrophosphate ammonium | 116057-57-9 | Endogenous Metabolite | ||
Farnesyl pyrophosphate ammonium salt 是一种 15 碳类异戊二烯，是甲羟戊酸 (MVA) 途径的代谢中间体。Farnesyl pyrophosphate ammonium salt 是一种 TRPM2 (TRP Channel) 激动剂，可激活 TRPM2 打开，使离子流入到细胞内。 | |||||
| GC39488 | GFB-8438 | 2304549-73-1 | - | ||
GFB-8438 is a novel, potent, and subtype selective TRP channel subfamily C (TRPC) inhibitor that is equipotent against TRPC4 and TRPC5 with IC50 of 0.18 μM and 0.29 μM, and shows excellent selectivity against TRPC6, other TRP family members , NaV 1.5, as well as limited activity against the hERG channel. | |||||
| GC38465 | GsMTx4 | 1209500-46-8 | TRP Channel | ||
GsMTx4是一种由34个氨基酸组成的蜘蛛毒素肽，属于huwentoxin-1家族。 | |||||
| GC12763 | Bax channel blocker | 335165-68-9 | Bax | ||
Bax 通道阻滞剂是 BAX（一种凋亡调节剂）的选择性变构抑制剂。 Bax 通道阻滞剂直接与 BAX 结合并变构抑制 BAX 活化。 Bax 通道阻滞剂具有研究由 BAX 依赖性细胞死亡介导的疾病的潜力。 | |||||
| GC37659 | Sodium Channel inhibitor 1 | 1198117-23-5 | Sodium Channel | ||
Sodium Channel inhibitor1是新型的选择性电压门控钠离子通道，可用于疼痛治疗。 | |||||
| GC31167 | Sodium Channel inhibitor 2 | 653573-60-5 | Sodium Channel | ||
SodiumChannelinhibitor2是一个钠通道阻断剂，来自专利WO2004011439A2，化合物3c。 | |||||
| GC32616 | Calcium channel-modulator-1 | 136941-70-3 | Calcium Channel | ||
Calciumchannel-modulator-1是钙离子通道(calciumchannel)调节剂，阻塞主动脉收缩的IC50值为0.8μM。 | |||||
| GC36519 | M2 ion channel blocker | 1190215-03-2 | Influenza virus | ||
M2 ion channel blocker 能抑制和阻断M2离子通道，能抗病毒。 | |||||
| GC30977 | Ca2+ channel agonist 1 | 1402821-24-2 | CDK | ||
Ca2+channelagonist1是一种N-型钙离子通道(N-typeCa2+channel)激动剂和Cdk2的抑制剂，EC50分别为14.23μM和3.34μM，对运动神经终端功能障碍有潜在疗效。 | |||||
| GC75617 | Calcium Channel antagonist 2 | 874370-15-7 | - | ||
Calcium Channel antagonist 2 (化合物 154) 是一种 calcium channel 拮抗剂 (IC50=5-20 μM)，可用于 Ca2+ 通道介导的疾病，如疼痛和糖尿病等。 | |||||
| GC75618 | Calcium Channel antagonist 3 | 687573-14-4 | - | ||
Calcium Channel antagonist 3 (compound 397)?是一种电压门控钙通道抑制剂，IC50?值为?5-20μM。 | |||||
| GC75623 | Calcium Channel antagonist 4 | 687574-49-8 | - | ||
Calcium Channelantagonist 4 (compound 189)?是一种电压门控钙通道抑制剂，IC50?值为?5-20μM。 | |||||
| GC75957 | Sodium Channel inhibitor 4 | 587843-16-1 | - | ||
Sodium Channel inhibitor 4 是钠通道抑制剂。 | |||||
| GB40250 | K+ Channel inhibitor 1734 | 343240-54-0 | - | ||
Building block for synthesis of dihydropyrazolopyrimidine inhibitors of Kv1.5 (IKur). The ethylester analog of inhibitor 1734 is a modest inhibitor itself (IC50 value 1.1 µM for human Kv1.5), but exhibiting encouraging KV1.5 versus L-type calcium channel selectivity. | |||||
| GB40255 | Kv1.3 Channel blocker 42 | 2108780-57-8 | - | ||
Potassium channel blocker, selective in blocking the Kv1.3 current (IC50: <50 nM); Selectivity: 25-fold over Kv1.1 and 24-fold over Kv1.5 | |||||
| GC69343 | KV2 channel inhibitor-1 | 689297-68-5 | Potassium Channel | ||
KV2 channel inhibitor-1 是一种选择性 KV2 通道抑制剂，对 KV2.1 和 KV2.2 的 IC50 分别为 0.2 μM 和 0.41 μM。 KV2 channel inhibitor-1 对 KV1.2 具有良好的选择性 (IC50>10 μM)。 KV2 channel inhibitor-1 比 NaV 通道和其他 KV 通道的选择性高 10 倍以上，并且在 CaV 通道上表现出弱活性。 | |||||
| GC75469 | NaV1.2/1.6 channel blocker-1 | 1199944-04-1 | - | ||
NaV1.2/1.6 channel blocker-1 是一种有效的 NaV1.2/1.6 channel 阻滞剂，抑制 rNaV1.6 和 hNaV1.2 的 IC50 值分别为 9.8 和 24.4 μM。NaV1.2/1.6 channel blocker-1 可用于全身性癫痫的研究。 | |||||
| GC36409 | Kv3, Channel Containing Protein 567-585 | - | Peptides | ||
Kv3, Channel Containing Protein (567-585) 是Kv3.1b 通道蛋白的567-586 氨基酸肽。Kv3 channel protein 在含有pallidal 神经元的 PV 蛋白表达。 | |||||
| GC31178 | N-type calcium channel blocker-1 | 241499-17-2 | Calcium Channel | ||
N-typecalciumchannelblocker-1是有口服活性的麻醉剂，可阻断N型钙离子通道(N-typecalciumchannels)，在IMR32试验中IC50值为0.7μM。 | |||||
| GL10010 | Ion Channel Compound Library | - | Screening Libraries | ||
350种离子通道相关化合物的独特集合，用于高通量筛选(HTS)和高内涵筛选(HCS)。 | |||||
| GA22956 | H-Trp-Trp-Trp-OH | 59005-82-2 | - | ||
Tritryptophan, WWW, a highly hydrophobic tripeptide used as a model in phase distribution studies. | |||||
| GP21317 | Trp | - | Peptide Hormones | ||
Triptorelin Acetate | |||||
| GA23949 | Z-Trp-Trp-OH | 57850-17-6 | - | ||