关于 "Cancer stem cell" 的结果19+ 个结果

A selective cancer stem cell inhibitor

CellFluor™ GST是一种细胞可渗透的淬灭荧光探针，用于检测贴壁或悬浮细胞、细胞或组织裂解物或纯化酶制剂中的泛谷胱甘肽S-转移酶活性。

Primes stem cells for differentiation

Purmorphamine是第一个针对Smoothened蛋白开发的小分子激动剂, 能够直接结合并激活Smo,阻断BODIPY-cyclopamine与Smo结合。

MG-132是一种强效、可逆和细胞渗透的蛋白酶体抑制剂，属于合成肽醛类。

A cell-permeable ceramide analog

A selective, cell-permeable EZH2 inhibitor

N6F11 is a novel, selective and potent inducer of iron death with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells.

An anti-cancer celecoxib analog

奥沙利铂（Oxaliplatin）是一种用于治疗癌症的细胞毒性化疗药物。

Dorsomorphin（Compound C）是一种细胞渗透的AMPK抑制剂。

GDC-0449 (Vismodegib)是一种具有口服活性和高效选择性的Smoothened（SMO）受体抑制剂，可抑制Hedgehog信号通路，IC 50 值为3.0nM。同时，也可抑制P-gp和ABCG2的活性，IC 50 值分别为3.0μM和1.4μM。

Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.

Natural curcuminoid with roles in cancer and inflammation

CHIR-99021是最常用的GSK-3β抑制剂，被认为是标准的小分子Wnt激动剂。

Natural curcuminoid with roles in Alzheimer’s, cancer, and inflammation

A Ras inhibitor with anti-cancer and anti-atherogenic activity

UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.

Mycro 3 is a potent and selective inhibitor of c-Myc in whole cell assays. Mycro 3 also shows weak inhibitory activity against AP-1.