关于 "Cancer stem cell" 的结果7+ 个结果
- ZINC05007751CAS: 591239-68-8
ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM, shows antiproliferative activity against a panel of human cancer cell lines and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
- GSK215CAS: 2743427-26-9
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader, which exerts FAK degradation in A549 non-small-cell lung cancer cells with DC50 of 1.3 nM by a strong time-dependence way and maximal degradation (Dmax) near the limit of the assay quantification (Dmax 99%).
- (E/Z)-BCICAS: 15982-84-0
(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC13961 | ISCK03 | 945526-43-2 | c-Kit | ||
An inhibitor of SCF/c-kit signaling | |||||
| GC14898 | Tie2 kinase inhibitor | 948557-43-5 | Others | ||
Tie2 kinase inhibitor是一种可逆的选择性Tie2抑制剂，IC50为250 nM。 | |||||
| GC15647 | ID-8 | 147591-46-6 | DYRK | ||
A cell culture supplement for maintaining embryonic stem cell pluriotency | |||||
| GC63626 | ZINC05007751 | 591239-68-8 | Others | ||
ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM, shows antiproliferative activity against a panel of human cancer cell lines and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation. | |||||
| GC64888 | GSK215 | 2743427-26-9 | FAK | ||
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader, which exerts FAK degradation in A549 non-small-cell lung cancer cells with DC50 of 1.3 nM by a strong time-dependence way and maximal degradation (Dmax) near the limit of the assay quantification (Dmax 99%). | |||||
| GC25000 | (E/Z)-BCI | 15982-84-0 | ROS | ||
(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells. | |||||
| GC12058 | TCS 359 | 301305-73-7 | FLT3 | ||
A cell-permeable FLT3 inhibitor | |||||