关于 "Cytoskeleton & Motor Proteins" 的结果177+ 个结果

Amyloid β-protein (1-40) that is N-terminally modified with the fluorescent dye (7-diethylaminocoumarin-3-yl)carbonyl (DAC or DEAC). This derivative can be utilized to assess the binding properties of amyloid β-protein (1-40) for various membranes since it behaves very similar to the native peptide. In aqueous environments the fluorophore is almost non-fluorescent whereas binding to membranes results in an increase in fluorescence intensity (Λex = 430 nm, Λem = 470 nm). Increases in the GM1 ganglioside and cholesterol content in the lipid bilayers facilitated the binding of this peptide. For phosphatidylcholine and phosphatidylserine no affinity was observed.

Amyloid precursor protein (APP) β-secretase from human brain cleaves full-length APP at the amino terminus of the amyloid β-protein (Aβ) sequence, thus leading to the generation and extracellular release of β-cleaved soluble APP and a corresponding cell-associated carboxy-terminal fragment. The subsequent cleavage of the C-terminal fragment by γ-secretase(s) leads to the formation of Aβ. This new peptide represents a potent substrate analog inhibitor of APP β-secretase with IC?? = 30 nM.

HIV-1 Rev 34-50（HIV-1 rev 蛋白 (34-50)）是一种 17-aa 肽，来源于 HIV-1 中 Rev 的 Rev 反应元件 (RRE) 结合域，具有抗 HIV- 1个活动。

An encephalitogenic peptide

Intramolecularly quenched fluorescent substrate containing the ortho-aminobenzoyl (Abz) / N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor / acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence targeted by β-secretase BACE (β-site APP-cleaving activity). This FRET substrate is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2).

Fluorescently labeled Aβ40, which may be immobilized.

A 15-residue cyclized APP fragment

Fluorogenic (FRET) substrate for pro-memapsin-2 containing the β-secretase site of the Swedish mutation of APP, SEVNLDAEF.

CGHGNKSGLMVGGVV.

Membrane-permeable inhibitor of Aβ (1-40) fibrillogenesis.

This fluorescent (FRET) peptide substrate contains the wild-type amyloid precursor protein (APP) β-secretase cleavage site. Mca-SEVKMDAEFRK(Dnp)RR- amide has been used for assaying β-secretase-like activity of thimet oligopeptidase (TOP, EC 3.4.24.15). The results suggested that TOP is a potential β-secretase candidate and is involved in the processing of APP in vivo. See also L-1905.

一种肺表面活性物质蛋白A的多肽片段。

A substrate-competitive inhibitor of PKCζ activity

Fluorogenic (FRET) substrate for pro-memapsin-2 containing the β-secretase site EVNLDAEF of the Swedish mutation of APP. The kinetic parameters at pH 4.5 are Km = 5.4 µM and kcat = 0.24 min?¹.

MD-2-CIRP蛋白相互作用的肽抑制剂

A sensitive fluorogenic (FRET) substrate developed for the analysis of γ-secretase from post mortem non-Alzheimer's and Alzheimer's disease human brain isolates.

Intramolecularly quenched fluorescent, presenilin-dependent substrate for assaying γ-secretase activity. The FRET substrate has been used for partial purification and characterization of γ-secretase from post-mortem human brain.

A synthetic peptide inhibitor of PKA

A PKCα inhibitor

PKCε Inhibitor Peptide，也称为 εV1-2，是一种蛋白激酶 C ε (PKCε) 衍生肽，作为选择性 PKCε 抑制剂，抑制 PKCε 的易位 。

Control peptide for LL37.

一种实验性自身免疫性葡萄膜视网膜炎的肽诱导剂

一种实验性自身免疫性葡萄膜视网膜炎的肽诱导剂

一个肽。