SP-A (196-215) (human) (trifluoroacetate salt)

Surfactant protein A (SP-A) (196-215) is a synthetic peptide that corresponds to amino acids 196-215 of the C-terminal carbodrate recognition domain of human SP-A.¹ It inhibits LPS-induced TNF-α release in JAWSII mouse dendritic cells when used at concentrations of 1 and 10 µM. SP-A (196-215) (75 µM) induces phagocytosis of P. aeruginosa by JAWSII cells.² Intratracheal administration of SP-A (196-215) (50 µg/animal) decreases disease severity and lung colony forming units in a mouse model of P. aeruginosa infection.