关于 "Cancer stem cell" 的结果16+ 个结果
- Glaucocalyxin ACAS: 79498-31-0
Glaucocalyxin A is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx with antitumor and anti-inflammatory activity. Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells.
- PI-273CAS: 925069-34-7
PI-273, the first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM, can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis.
- Rotundic acidCAS: 20137-37-5
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways.
- Paris saponin VIICAS: 68124-04-9
Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC13176 | CP21R7 | 125314-13-8 | GSK-3 | ||
A GSK3β inhibitor used to differentiate stem cells | |||||
| GC38606 | Glaucocalyxin A | 79498-31-0 | Other Apoptosis | ||
Glaucocalyxin A is a biologically active ent-kauranoid diterpenoid isolated from Rabdosia japonica var. glaucocalyx with antitumor and anti-inflammatory activity. Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells. | |||||
| GC39155 | PI-273 | 925069-34-7 | Other Apoptosis | ||
PI-273, the first reversibly and specific phosphatidylinositol 4-kinase (PI4KIIα) inhibitor with an IC50 of 0.47 μM, can inhibit breast cancer cell proliferation, block the cell cycle and induce cell apoptosis. | |||||
| GC64402 | MHY-1685 | 27406-31-1 | mTOR | ||
MHY-1685 is a novel mTOR inhibitor, which attenuates senescence by modulating autophagy through the inhibition of mTOR in human cardiac stem cells. | |||||
| GC38609 | Rotundic acid | 20137-37-5 | Other Apoptosis | ||
Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) cell lines.RA induces cell cycle arrest, DNA damage, and apoptosis by modulating the AKT/mTOR and MAPK pathways. | |||||
| GC16157 | 740 Y-P | 1236188-16-1 | PI3K | ||
740 Y-P是一种PI3K激活剂，浓度为20μM 。 | |||||
| GC15742 | OSU-03012 (AR-12) | 742112-33-0 | Autophagy | ||
An anti-cancer celecoxib analog | |||||
| GC17243 | Dorsomorphin (Compound C) | 866405-64-3 | Autophagy | ||
Dorsomorphin（Compound C）是一种细胞渗透的AMPK抑制剂。 | |||||
| GC36855 | Paris saponin VII | 68124-04-9 | Autophagy | ||
Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway. | |||||
| GC16702 | CHIR-99021 (CT99021) | 252917-06-9 | Autophagy | ||
CHIR-99021是最常用的GSK-3β抑制剂，被认为是标准的小分子Wnt激动剂。 | |||||
| GC17690 | Cromolyn sodium | 15826-37-6 | GSK-3 | ||
A mast cell stabilizer | |||||
| GC12045 | LY 303511 | 154447-38-8 | Potassium Channel | ||
An inhibitor of cell proliferation | |||||
| GC17199 | PIK-90 | 677338-12-4 | DNA-PK | ||
Potent, cell permeable PI3K inhibitor | |||||
| GC17984 | FPA 124 | 902779-59-3 | Akt | ||
A cell-permeable Akt inhibitor | |||||
| GC11190 | AMPK activator | 849727-81-7 | AMPK | ||
A cell-permeable activator of AMPK | |||||
| GC17837 | DMAT | 749234-11-5 | Casein Kinase | ||
A cell-permeable inhibitor of CK2 | |||||