关于 "Cancer stem cell" 的结果13+ 个结果
- NFAT Inhibitor (cell-permeable) (trifluoroacetate salt)
A cell-permeable form of NFAT inhibitor
- ZINC05007751CAS: 591239-68-8
ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM, shows antiproliferative activity against a panel of human cancer cell lines and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
- N6F11CAS: 851398-76-0
N6F11 is a novel, selective and potent inducer of iron death with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells.
- Ammonium iron(III) citrateCAS: 1185-57-5
Ammonium ferric citrate (Ferric ammonium citrate, Ammonium iron(III) citrate, Iron ammonium citrate, FerriSeltz) induces ferroptosis in non-small-cell lung carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC52384 | NFAT Inhibitor (cell-permeable) (trifluoroacetate salt) | - | Bone Growth & Remodeling | ||
A cell-permeable form of NFAT inhibitor | |||||
| GC10171 | Puromycin aminonucleoside | 58-60-6 | Aminopeptidase | ||
A glomerular epithelial cell toxin | |||||
| GC60278 | OT-82 | 1800487-55-1 | Metabolism | ||
OT-82 is a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with average IC50s of 13.03 ??nM in non-HP cancer cells and 2.89? ?nM in HP cancer cells, respectively. | |||||
| GC16630 | Erastin | 571203-78-6 | Ferroptosis | ||
Erastin是一种能够穿透细胞膜的铁死亡激活剂和抗肿瘤药物，它选择性地作用于表达癌基因RAS的细胞。 | |||||
| GC11908 | Cisplatin | 15663-27-1 | Ferroptosis | ||
顺铂是最好的、最早的基于金属的化疗药物之一，用于治疗广泛的实体癌症，如睾丸癌、卵巢癌、膀胱癌、肺癌、宫颈癌、头颈部肿瘤和胃癌等。 | |||||
| GC16361 | Geldanamycin | 30562-34-6 | Bacterial | ||
Binds Hsp90 and GRP94, inhibits growth of cancer cells | |||||
| GC63626 | ZINC05007751 | 591239-68-8 | Others | ||
ZINC05007751 is a potent NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM, shows antiproliferative activity against a panel of human cancer cell lines and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line. DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation. | |||||
| GC44775 | PTP1B Inhibitor | 765317-72-4 | Diabetes | ||
A cell-permeable allosteric inhibitor of PTP1B | |||||
| GC91380 | N6F11 | 851398-76-0 | Ubiquitination/ Proteasome | ||
N6F11 is a novel, selective and potent inducer of iron death with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells. | |||||
| GC61895 | Ammonium iron(III) citrate | 1185-57-5 | Ferroptosis | ||
Ammonium ferric citrate (Ferric ammonium citrate, Ammonium iron(III) citrate, Iron ammonium citrate, FerriSeltz) induces ferroptosis in non-small-cell lung carcinoma through the inhibition of GPX4-GSS/GSR-GGT axis activity. | |||||
| GC50635 | Poly Vinyl Alcohol 1788 | 9002-89-5 | Others | ||
聚乙烯醇是一种水溶性聚合物，由于其优异的机械和化学性能，已广泛应用于不同行业。 | |||||
| GC15286 | Dimethyl DL-Glutamate (hydrochloride) | 13515-99-6 | Amino acid metabolism | ||
A cell-permeant glutamate derivative | |||||
| GC42824 | APC 366 (trifluoroacetate salt) | - | Metabolism | ||
A mast cell tryptase inhibitor | |||||