NFAT inhibitor (cell-permeable) is a cell-permeable form of NFAT inhibitor , an inhibitor of calcineurin-nuclear factor of activated T cells (NFAT) signaling.1 It inhibits the production of IL-12p40 and nitric oxide (NO) in LPS- and IFN-γ-induced mouse bone marrow-derived macrophages (BMDMs) when used at concentrations of 50 or 100 µM. NFAT inhibitor (cell-permeable) (1 mg/kg) prevents increases in kidney weight and urine albumin levels in a db/db mouse model of diabetic nephropathy.2 It improves fracture healing in a rat model of ovariectomy-induced osteoporosis when administered at a dose of 100 µg/kg for 16 weeks post-fracture.3 NFAT inhibitor (cell-permeable) (1 mg/kg) decreases disease severity in IL-10 knockout mice in a model of colitis induced by piroxicam .1
1.Elloumi, H.Z., Maharshak, N., Rao, K.N., et al.A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitisPLoS One7(3)e34172(2012) 2.Zhang, L., Li, R., Shi, W., et al.NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db miceBr. J. Pharmacol.170(2)426-439(2013) 3.Hou, C., Wang, X., Jiang, W., et al.Peptide 11R?VIVIT promotes fracture healing in osteoporotic ratsInt. J. Mol. Med.48(2)162(2021)