关于 "FAS" 的结果22 个结果
- Euphorbia Factor L2CAS: 218916-51-9
Euphorbia factor L2 是从大戟种子中分离得到的一种赤藓烷二萜 (Euphorbia lathyris L.)，传统上用于治疗癌症。Euphorbia factor L2 显示强烈的细胞毒性并通过线粒体途径诱导细胞凋亡。
- NFAT Transcription Factor RegulatorCAS: 245747-71-1
NFAT Transcription Factor Regulator 是一种 IL-2 合成抑制剂，IC50 为 182 nM。
- Factor D inhibitor 6CAS: 1386455-51-1
Factor D inhibitor 6 是一种有效的，高选择性，具有口服活性的因子 D (factor D) 抑制剂，IC50 为 30 nM，Kd 为 6 nM。Factor D inhibitor 6 对因子 B，激肽和凝集素补体途径激活以及广泛的受体，离子通道，激酶和蛋白酶等无活性。
- Complement factor D-IN-2CAS: 1903742-34-6
Complement factor D-IN-2 是一种 complement factor D 的抑制剂。Complement factor D-IN-2 在替代补体途径的早期和关键时刻靶向 factor D 并抑制补体级联反应。Complement factor D-IN-2 可用于自身免疫疾病的研究。详细信息请参考专利文献 WO2015130838A1 中的化合物 190。
- Melanocyte stimulating hormone release inhibiting factorCAS: 2002-44-0
A tripeptide with diverse biological activities
- Simlukafusp alfaCAS: 1776942-10-9
Simlukafusp alfa（FAP-IL2v）是一种免疫细胞因子，包含抗成纤维细胞活化蛋白α（FAPα）的抗体和仅结合IL-2Rβγ的IL-2变体。
- NFAT Inhibitor (cell-permeable) (trifluoroacetate salt)
A cell-permeable form of NFAT inhibitor
- trans-ChalconeCAS: 614-47-1
Trans-Chalcone, the backbone of flavonoids, also is a potent fatty acid synthase (FAS) with IC50 of 17.1 μg/mL, and α-amylase inhibitor, causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7, exerting antifungal and anticancer activities.
- (Rac)-IndoximodCAS: 26988-72-7
(Rac)-Indoximod(1-Methyl-DL-tryptophan)是吲哚胺-2,3-双加氧酶(IDO)抑制剂。(Rac)-Indoximod和IFN-γ联用显著降低了表达α-SMA的人心肌成纤维细胞活性，并通过上调IRF-1，Fas和FasL基因诱导凋亡(apoptosis)。
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC60157 | Euphorbia Factor L2 | 218916-51-9 | Apoptosis | ||
Euphorbia factor L2 是从大戟种子中分离得到的一种赤藓烷二萜 (Euphorbia lathyris L.)，传统上用于治疗癌症。Euphorbia factor L2 显示强烈的细胞毒性并通过线粒体途径诱导细胞凋亡。 | |||||
| GC43645 | Extracellular Death Factor | 960129-66-2 | Bacterial Diseases | ||
A quorum-sensing signal peptide | |||||
| GC31934 | NFAT Transcription Factor Regulator | 245747-71-1 | Interleukin Related | ||
NFAT Transcription Factor Regulator 是一种 IL-2 合成抑制剂，IC50 为 182 nM。 | |||||
| GC64878 | Factor D inhibitor 6 | 1386455-51-1 | Complement System | ||
Factor D inhibitor 6 是一种有效的，高选择性，具有口服活性的因子 D (factor D) 抑制剂，IC50 为 30 nM，Kd 为 6 nM。Factor D inhibitor 6 对因子 B，激肽和凝集素补体途径激活以及广泛的受体，离子通道，激酶和蛋白酶等无活性。 | |||||
| GC64892 | Factor B-IN-1 | 1481631-75-7 | Complement System | ||
Factor B-IN-1 是一种 Factor B 抑制剂，详细信息请参见专利 WO2013164802A1，Example 24。 | |||||
| GC48659 | Umbelliprenin | 532-16-1; 23838-17-7 | Macrophage Migration Inhibitory Factor | ||
A prenylated coumarin with diverse biological activities | |||||
| GC62901 | Complement factor D-IN-2 | 1903742-34-6 | Complement System | ||
Complement factor D-IN-2 是一种 complement factor D 的抑制剂。Complement factor D-IN-2 在替代补体途径的早期和关键时刻靶向 factor D 并抑制补体级联反应。Complement factor D-IN-2 可用于自身免疫疾病的研究。详细信息请参考专利文献 WO2015130838A1 中的化合物 190。 | |||||
| GP10066 | Melanocyte stimulating hormone release inhibiting factor | 2002-44-0 | Neuroscience Peptides | ||
A tripeptide with diverse biological activities | |||||
| GC74605 | Simlukafusp alfa | 1776942-10-9 | Interleukin Related | ||
Simlukafusp alfa（FAP-IL2v）是一种免疫细胞因子，包含抗成纤维细胞活化蛋白α（FAPα）的抗体和仅结合IL-2Rβγ的IL-2变体。 | |||||
| GC44078 | LL-37 amide (trifluoroacetate salt) | - | Tuberculosis | ||
An antimicrobial peptide | |||||
| GC90631 | LL-37 (human) (scrambled) (trifluoroacetate salt) | - | Microbiology & Virology | ||
LL-37（人类）的阴性对照。 | |||||
| GC48358 | Thymulin (acetate hydrate) | - | Thyroid hormone Receptor | ||
A peptide hormone | |||||
| GC42661 | A-54556B | 1629166-56-8 | Bacterial Diseases | ||
An acyldepsipeptide antibiotic | |||||
| GC44540 | PAF C-16 Carboxylic Acid | 129879-41-0 | Allergy | ||
PAF with a reactive carboxylic acid group | |||||
| GC60725 | Cortisone | 53-06-5 | Glucocorticoids & Mineralocorticoids | ||
Cortisone(17-Hydroxy-11-dehydrocorticosterone)是一种用于研究感染或过敏的激素药物。 | |||||
| GC52384 | NFAT Inhibitor (cell-permeable) (trifluoroacetate salt) | - | Bone Growth & Remodeling | ||
A cell-permeable form of NFAT inhibitor | |||||
| GC41450 | PAF C-18:1 | 85966-90-1 | Coagulation & Hemostasis | ||
A natural PAF analog | |||||
| GC72103 | Kp7-6 | 629628-53-1 | Apoptosis | ||
Kp7-6是一种Fas模拟肽，是一种Fas/FasL拮抗剂。 | |||||
| GC42943 | Bischloroanthrabenzoxocinone | 866022-28-8 | FXR & LXR | ||
An inhibitor of FAS-II | |||||
| GC15586 | AP1903 | 195514-63-7 | Other Apoptosis | ||
AP1903是一种二价"二聚化"化合物，可与FKBP结合并诱导Fas交联。 | |||||
| GC61896 | trans-Chalcone | 614-47-1 | Fatty Acid Synthase (FASN) | ||
Trans-Chalcone, the backbone of flavonoids, also is a potent fatty acid synthase (FAS) with IC50 of 17.1 μg/mL, and α-amylase inhibitor, causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7, exerting antifungal and anticancer activities. | |||||
| GC61750 | (Rac)-Indoximod | 26988-72-7 | IDO | ||
(Rac)-Indoximod(1-Methyl-DL-tryptophan)是吲哚胺-2,3-双加氧酶(IDO)抑制剂。(Rac)-Indoximod和IFN-γ联用显著降低了表达α-SMA的人心肌成纤维细胞活性，并通过上调IRF-1，Fas和FasL基因诱导凋亡(apoptosis)。 | |||||