关于 "Bromodomain" 的结果39+ 个结果
- Bromodomain IN-1CAS: 1914120-48-1
Bromodomain IN-1 是一种有效的选择性 Bromodomain 抑制剂，详细信息请参考专利文献 WO2016069578A1 中的化合物 4。
Epigenetic Reader Domain - Bromodomain inhibitor-8CAS: 1300031-70-2
Bromodomain inhibitor-8 (Intermediate 21) 是BET 溴端结构域 的抑制剂，可用于治疗自身免疫性和炎症类疾病。
Epigenetic Reader Domain - BET bromodomain inhibitor 1CAS: 2411226-02-1
BET bromodomain inhibitor 1 是一种具有口服活性的，选择性 BET 溴结构域抑制剂，对 BRD4 的 IC50 为 2.6 nM。BET bromodomain inhibitor 1 与 BRD2(2)，BRD3(2)，BRD4(1)，BRD4(2) 和 BRDT(2) 高亲和力结合 (Kd 值分别为 1.3 nM、1.0 nM、3.0 nM、1.6 nM、2.1 nM)。BET bromodomain inhibitor 1 具有抗癌活性。
Epigenetic Reader Domain - BET bromodomain inhibitor 4CAS: 2407658-41-5
BET bromodomain inhibitor 4（实施例7）是BET溴结构域的抑制剂。
Epigenetic Reader Domain - BET bromodomain inhibitorCAS: 1380087-89-7
BET 溴结构域抑制剂是从专利 WO/2015/153871A2 化合物实施例 11 中提取的一种有效的 BET 抑制剂。
Epigenetic Reader Domain - ACBI1CAS: 2375564-55-7
ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC16531 | Bromodomain Inhibitor, (+)-JQ1 | 1268524-70-4 | Ligand for Target Protein for PROTAC | ||
A selective inhibitor of BET bromodomains | |||||
| GC35557 | Bromodomain IN-1 | 1914120-48-1 | Epigenetic Reader Domain | ||
Bromodomain IN-1 是一种有效的选择性 Bromodomain 抑制剂，详细信息请参考专利文献 WO2016069578A1 中的化合物 4。 | |||||
| GC35558 | Bromodomain inhibitor-8 | 1300031-70-2 | Epigenetic Reader Domain | ||
Bromodomain inhibitor-8 (Intermediate 21) 是BET 溴端结构域 的抑制剂，可用于治疗自身免疫性和炎症类疾病。 | |||||
| GC63528 | BET bromodomain inhibitor 1 | 2411226-02-1 | Epigenetic Reader Domain | ||
BET bromodomain inhibitor 1 是一种具有口服活性的，选择性 BET 溴结构域抑制剂，对 BRD4 的 IC50 为 2.6 nM。BET bromodomain inhibitor 1 与 BRD2(2)，BRD3(2)，BRD4(1)，BRD4(2) 和 BRDT(2) 高亲和力结合 (Kd 值分别为 1.3 nM、1.0 nM、3.0 nM、1.6 nM、2.1 nM)。BET bromodomain inhibitor 1 具有抗癌活性。 | |||||
| GC73742 | BET bromodomain inhibitor 4 | 2407658-41-5 | Epigenetic Reader Domain | ||
BET bromodomain inhibitor 4（实施例7）是BET溴结构域的抑制剂。 | |||||
| GC16299 | BET bromodomain inhibitor | 1380087-89-7 | Epigenetic Reader Domain | ||
BET 溴结构域抑制剂是从专利 WO/2015/153871A2 化合物实施例 11 中提取的一种有效的 BET 抑制剂。 | |||||
| GC10174 | SGC-CBP30 | 1613695-14-9 | Histone Acetyltransferases | ||
A potent inhibitor of CREBBP/EP300 bromodomains | |||||
| GC14199 | RVX-208 | 1044870-39-4 | HIV | ||
A selective BET bromodomain antagonist | |||||
| GC14699 | CPI-203 | 1446144-04-2 | Other Apoptosis | ||
A bioavailable inhibitor of BET bromodomains | |||||
| GC17482 | OF-1 | 919973-83-4 | Epigenetic Reader Domain | ||
A bromodomain probe for BRPF proteins | |||||
| GC15175 | BAZ2-ICR | 1665195-94-7 | Epigenetic Reader Domain | ||
A BAZ2A/B bromodomain inhibitor | |||||
| GC12440 | GSK 5959 | 901245-65-6 | Epigenetic Reader Domain | ||
An inhibitor of the BRPF1 bromodomain | |||||
| GC15789 | GSK2801 | 1619994-68-1 | Epigenetic Reader Domain | ||
A probe for BAZ2A/B bromodomains | |||||
| GC12588 | I-BRD9 | 1714146-59-4 | Epigenetic Reader Domain | ||
A BRD9 bromodomain inhibitor | |||||
| GC16817 | BI-9564 | 1883429-22-8 | Epigenetic Reader Domain | ||
A selective BRD9/7 bromodomain inhibitor | |||||
| GC16726 | BI-7273 | 1883429-21-7 | Epigenetic Reader Domain | ||
A potent BRD9 bromodomain inhibitor | |||||
| GC10382 | CPI-637 | 1884712-47-3 | Histone Acetyltransferases | ||
An inhibitor of CBP/EP300 bromodomains | |||||
| GC13025 | GSK6853 | 1910124-24-1 | Epigenetic Reader Domain | ||
A selective chemical probe for the bromodomain of BRPF1 | |||||
| GC16763 | NI-57 | 1883548-89-7 | Epigenetic Reader Domain | ||
A BRPF bromodomain inhibitor | |||||
| GC14361 | PFI 3 | 1819363-80-8 | Epigenetic Reader Domain | ||
Probe for bromodomains of SMARCA2/4 and PB1(bromodomain 5) | |||||
| GC15375 | PFI-1 (PF-6405761) | 1403764-72-6 | Autophagy | ||
A BET bromodomain inhibitor | |||||
| GC10402 | Bromosporine | 1619994-69-2 | Epigenetic Reader Domain | ||
A non-specific bromodomain inhibitor | |||||
| GC13822 | (-)-JQ1 | 1268524-71-5 | Epigenetic Reader Domain | ||
A selective inhibitor of BET bromodomains | |||||
| GC35227 | ACBI1 | 2375564-55-7 | Other Apoptosis | ||
ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis. | |||||