关于 "Cell Cycle/Checkpoint" 的结果19+ 个结果

Hesperadin是一种竞争性ATP结合抑制剂，对Aurora B激酶的IC 50 为250nM。

Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.

MG-132是一种强效、可逆和细胞渗透的蛋白酶体抑制剂，属于合成肽醛类。

KU 55933是一种高效且特异的ATM激酶抑制剂，能够使人类肿瘤细胞对电离辐射和化疗药物更加敏感。KU 55933在体外的IC₅₀值为13nM，K i 值为2.2nM。

A cell-permeable ceramide analog

A selective, cell-permeable EZH2 inhibitor

Fasudil (HA-1077) HCl（法舒地尔；HA-1077；AT877）是一种非特异性RhoA/ROCK抑制剂，对ROCK1的K i 为0.33μM，IC 50 为0.158μM，对ROCK2和PKA、PKC、PKG的IC 50 分别为4.58μM、12.30μM、1.650μM。

An inhibitor of Cdks

A Chk1 inhibitor

An inhibitor of cyclin-dependent kinases

Glucosamine (2-amino-2-deoxy-D-glucose) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Glucosamine（GS） treatment selectively downregulates HIF-1α at the protein level in YD-8 cells via interference of production of the citric acid cycle metabolites.

DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.

Alisertib (MLN8237) 作为一种在研、可口服的选择性极光 A 激酶抑制剂，通常用于治疗实体瘤和血液系统恶性肿瘤。

Dorsomorphin（Compound C）是一种细胞渗透的AMPK抑制剂。

Acridine Orange是一种可穿透细胞的核酸选择性荧光染料， Acridine Orange可与DNA或RNA结合时产生荧光，与双链DNA结合时产生绿色荧光（激发光为488nm；发射光为530nm绿色荧光）。

UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.

Mycro 3 is a potent and selective inhibitor of c-Myc in whole cell assays. Mycro 3 also shows weak inhibitory activity against AP-1.

A selective cancer stem cell inhibitor

A selective, cell-permeable inhibitor of MLCK