关于 "c-RET" 的结果13 个结果
- δ-Secretase inhibitor 11CAS: 842964-18-5
Compound 11, a non-toxic and selective δ-secretase inhibitor (IC50=0.7 μM, in fluorescence-based assay) that interacts with both the active site and allosteric site of δ-secretase in Co-crystal structure analysis. The IC50 value of the compound 11 towards δ-secretase in Pala cells is 0.8 μM.
- DAPT (GSI-IX)CAS: 208255-80-5
DAPT (GSI-IX) 是一种具有口服活性的 γ-分泌酶抑制剂，对人原代神经元培养物中产生的总淀粉样蛋白-β (Aβ) 和 Aβ42 的 IC50 分别为 115 nM 和 200 nM。
- Urolithin CCAS: 165393-06-6
UrolithinC，是鞣花酸的多酚类肠道微生物代谢产物，是胰岛素分泌(insulinsecretion)的葡萄糖依赖性激活剂。UrolithinC是一种L型Ca2+通道开放剂，可增强Ca2+的流入。UrolithinC通过线粒体介导的途径诱导细胞凋亡(apoptosis)，并刺激活性氧(ROS)的形成。
- Calcium dobesilateCAS: 20123-80-2
Calcium dobesilate (calcium dihydroxy-2,5-benzenesulfonate) is a small molecule that has been widely used for treating diabetic retinopathy and chronic venous insufficiency.
- YUM70CAS: 423145-35-1
YUM70 is a potent inhibitor of glucose-regulated protein 78 (GRP78) inhibitor with an IC50 of 1.5 μM. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.Although YUM70 inhibits GRP78 enzymatic activity, it increases the expression of GRP78 by increasing the chaperone translation mechanism.
Apoptosis
| 货号 | 产品名称 | CAS号 | 靶点 / 通路 | 引用 | 结构 |
|---|---|---|---|---|---|
| GC66048 | δ-Secretase inhibitor 11 | 842964-18-5 | Caspase | ||
Compound 11, a non-toxic and selective δ-secretase inhibitor (IC50=0.7 μM, in fluorescence-based assay) that interacts with both the active site and allosteric site of δ-secretase in Co-crystal structure analysis. The IC50 value of the compound 11 towards δ-secretase in Pala cells is 0.8 μM. | |||||
| GC15896 | Z-Ile-Leu-aldehyde | 161710-10-7 | Gamma Secretase | ||
Z-Ile-Leu-aldehyde (Z-IL-CHO) 是一种有效的、竞争性的 γ-分泌酶和缺口肽醛抑制剂。 | |||||
| GC12942 | DAPT (GSI-IX) | 208255-80-5 | Autophagy | ||
DAPT (GSI-IX) 是一种具有口服活性的 γ-分泌酶抑制剂，对人原代神经元培养物中产生的总淀粉样蛋白-β (Aβ) 和 Aβ42 的 IC50 分别为 115 nM 和 200 nM。 | |||||
| GC44943 | sPLA2 Inhibitor | 393569-31-8 | Transcription Factors | ||
An orally active inhibitor of sPLA2-IIA | |||||
| GC39798 | Scoulerine | 6451-73-6 | Microtubule/Tubulin | ||
A benzylisoquinoline alkaloid with diverse biological activities | |||||
| GC15364 | L-685,458 | 292632-98-5 | Other Apoptosis | ||
A γ-secretase inhibitor | |||||
| GC10040 | Arylquin 1 | 1630743-73-5 | PAR4 | ||
A Par-4 secretagogue | |||||
| GC12191 | LY-411575 | 209984-57-6 | Notch | ||
A γ-secretase inhibitor | |||||
| GC50282 | EC 19 | 1010694-08-2 | Other Apoptosis | ||
Synthetic retinoid; induces differentiation of stem cells | |||||
| GC60377 | Urolithin C | 165393-06-6 | Reactive Oxygen Species | ||
UrolithinC，是鞣花酸的多酚类肠道微生物代谢产物，是胰岛素分泌(insulinsecretion)的葡萄糖依赖性激活剂。UrolithinC是一种L型Ca2+通道开放剂，可增强Ca2+的流入。UrolithinC通过线粒体介导的途径诱导细胞凋亡(apoptosis)，并刺激活性氧(ROS)的形成。 | |||||
| GC19290 | PF-3084014 | 1290543-63-3 | Other Apoptosis | ||
An inhibitor of γ-secretase | |||||
| GC30240 | Calcium dobesilate | 20123-80-2 | Other Apoptosis | ||
Calcium dobesilate (calcium dihydroxy-2,5-benzenesulfonate) is a small molecule that has been widely used for treating diabetic retinopathy and chronic venous insufficiency. | |||||
| GC62388 | YUM70 | 423145-35-1 | Apoptosis | ||
YUM70 is a potent inhibitor of glucose-regulated protein 78 (GRP78) inhibitor with an IC50 of 1.5 μM. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.Although YUM70 inhibits GRP78 enzymatic activity, it increases the expression of GRP78 by increasing the chaperone translation mechanism. | |||||