GlpBio

SC 51089 free base

目录号: GC69865纯度: >98.00%
SC 51089 free base 是一种选择性的前列腺素受体 EP1 拮抗剂，对 EP1，TP，EP3 和 FP 受体的 Ki 值分别为 1.3，11.2，17.5 和 61.1 μM。SC 51089 free base 具有神经保护活性。
SC 51089 free base
Cas No.: 146033-03-6
规格价格库存数量操作
10mg¥1,440.00现货
1
25mg¥3,150.00现货
1
50mg¥5,580.00现货
1
100mg¥9,810.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

SC 51089 free base is a selective antagonist of prostaglandin E2 EP1 receptor, with Kis of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, EP3, and Ameliorated motor coordination and balance dysfunction.
Rescued long-term memory deficit.
Improved the expression of specific synaptic markers.
Reduced the number of huntingtin nuclear inclusions in the striatum and hippocampus.

[1]. Abramovitz M, et, al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biops Acta. 2000 Jan 17;1483(2):285-93.
[2]. Saleem S, et, al. Effects of EP1 receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice. J Neurosci Res. 2007 Aug 15;85(11):2433-40.
[3]. Anglada-Huguet M, et, al. Prostaglandin E2 EP1 receptor antagonist improves motor deficits and rescues memory decline in R6/1 mouse model of Huntington's disease. Mol Neurobiol. 2014 Apr;49(2):784-95.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
146033-03-6
分子式
C22H19ClN4O3
分子量
422.86 g/mol
溶解性
DMSO : 100 mg/mL (236.48 mM; Need ultrasonic)
保存条件
4°C, away from moisture and light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol