Sabinene is a bicyclic monoterpene found in a variety of plants, including Cannabis, that has antifungal and anti-inflammatory properties.1,2,3 It inhibits the growth of various fungi in vitro, including several species of Candida, Trichophyton, and Aspergillus (MICs = 0.16-5 μl/ml).3 Sabinene (0.32 μl/ml) prevents increases in nitrite production in RAW 264.7 macrophages stimulated by LPS and IFN-γ. It is cytotoxic to RAW 264.7 macrophages and HaCat keratinocytes when used at a concentration of 1.25 μl/ml. Formulations containing sabinene have been used as perfume additives.
1.Marchini, M., Charvoz, C., Dujourdy, L., et al.Multidimensional analysis of cannabis volatile constituents: Identification of 5,5-dimethyl-1-vinylbicyclo[2.1.1]hexane as a volatile marker of hashish, the resin of Cannabis sativa LJ. Chromatogr. A.1370200-215(2014) 2.Cao, Y., Zhang, H., Liu, H., et al.Biosynthesis and production of sabinene: Current state and perspectivesAppl. Microbiol. Biotechnol.102(4)1535-1544(2018) 3.Valente, J., Zuzarte, M., Gon?alves, M.J., et al.Antifungal, antioxidant and anti-inflammatory activities of Oenanthe crocata L. essential oilFood Chem. Toxicol.62349-354(2013)