Porcupine

Porcupine (Porc) protein may be involved in secretion or ER transport, as Wingless is retained in the ER in porcupine mutant Drosophila embryos. In C. elegans, the porcupine homolog mom-1 has a similar function in promoting secretion of the Wnt protein Mom-2. Porcupine has some homology to a family of o-acyl transferases and may be involved in lipid modification of Wnt proteins. A special form of monounsaturated palmitoylation has been detected on a serine residue in the Wnt protein and could be mediated by porc as well. The human Porcupine gene is implicated in a genetic disease, Focal dermal hypoplasia. Porcupine, encodes a multipass transmembrane ER protein, which is required for normal distribution of Wg in embryos. Porc stimulates the processing of Wg when expressed in Drosophila cells in vitro and is also necessary for the localization of Drosophila Wnt-3 on the axon tracts of the embryonic central nervous system.

Porcupine 相关产品(6)

GC12392 LGK-974
CAS: 1243244-14-5
纯度: >99.50%
LGK-974是一种高效且特异的Porcupine（PORCN）抑制剂。
GC13658 Wnt-C59
CAS: 1243243-89-1
纯度: >99.50%
Wnt-C59是Mboat（膜结合的O-酰脱糖酶）家族成员Porcupine（Porcn）的高度有效抑制剂，IC 50 值为74pM，能够抑制Wnt信号传导。
GC17708 IWP-L6
CAS: 1427782-89-5
纯度: >99.50%
A potent inhibitor of Porcupine
GC19299 Porcupine-IN-1
CAS: 2036044-77-4
纯度: >99.00%
An inhibitor of Wnt and hedgehog signaling
GC32877 GNF-6231
CAS: 1243245-18-2
纯度: >99.50%
GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.
GC34628 IWP-O1
CAS: 2074607-48-8
纯度: >99.00%
IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.

分类产品列表
货号	产品名称	CAS号	纯度
GC12392	LGK-974	1243244-14-5	>99.50%
GC12392	LGK-974是一种高效且特异的Porcupine（PORCN）抑制剂。
GC13658	Wnt-C59	1243243-89-1	>99.50%
GC13658	Wnt-C59是Mboat（膜结合的O-酰脱糖酶）家族成员Porcupine（Porcn）的高度有效抑制剂，IC 50 值为74pM，能够抑制Wnt信号传导。
GC17708	IWP-L6	1427782-89-5	>99.50%
GC17708	A potent inhibitor of Porcupine
GC19299	Porcupine-IN-1	2036044-77-4	>99.00%
GC19299	An inhibitor of Wnt and hedgehog signaling
GC32877	GNF-6231	1243245-18-2	>99.50%
GC32877	GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50 of 0.8 nM.
GC34628	IWP-O1	2074607-48-8	>99.00%
GC34628	IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.