GlpBio

HSP

HSP(热休克蛋白)

Heat shock proteins (HSPs) are a family of highly conserved proteins that are expressed, either constitutively or regulated inductively, in response to a wide range of physiological and environmental insults, such as heat shock. According to molecular weight, mammalian HSPs are classified into four subfamilies, including HSP90 (90 kDa), HSP70 (70 kDa), HSP60 (60 kDa) and small HSPs (15 to 30 kDa), among which HSP90 and HSP70 are two of the most studied stress-inducible HSPs. HSP90 is a highly abundant chaperone protein characterized by containing three relevant domains, including the N-terminal domain, the charged middle linker region and the C-terminal dimerization domain; while HSP70 is an ATP-dependent chaperone protein characterized by containing two distinct functional domains, including a peptide binding domain (PBD) and the amino-terminal ATPase domain (ABD). Collectively HSPs play a fundamental role in maintaining the stability of other cellular proteins.

HSP 相关产品(102)

  • GC37040 structure
    GC37040PU-H71 hydrochloride

    PU-H71 hydrochloride 是一种有效的 Hsp90 抑制剂，在 MDA-MB-468 细胞中，对 Hsp90 的 IC50 值为 51 nM。

  • GC38223 structure
    GC38223Dihydroberberine
    CAS: 483-15-8
    纯度: >98.00%

    Dihydroberberine是一种强效的haematopoietic prostaglandin D2 synthase (H-PGDS)抑制剂，IC 50 值为3.7μM。

  • GC38503 structure
    GC38503HSP27 inhibitor J2
    CAS: 2133499-85-9
    纯度: >99.00%

    HSP27抑制剂J2 (J2)是HSP27的抑制剂,能显著诱导异常HSP27二聚体形成,抑制HSP27大聚合物的生成。

  • GC39477 structure
    GC39477AMP-PCP disodium
    CAS: 7414-56-4
    纯度: >99.00%

    AMP-PCP disodium 是一种 ATP 类似物，可以以 Kd 值 为 3.8 μM 来结合到 Hsp90 的 N 末端结构域。AMP-PCP disodium 结合有利于 Hsp90 活性同型二聚体的形成。

  • GC40724 structure
    GC40724Heat Shock Protein Inhibitor II
    CAS: 1859-42-3
    纯度: >98.00%

    Prevents the synthesis of inducible heat shock proteins

  • GC41532 structure
    GC41532Benzisoxazole Hsp90 Inhibitor
    CAS: 1012788-65-6
    纯度: >98.00%

    Hsp90 chaperone inhibitor

  • GC41955 structure
    GC4195517-DMAG
    CAS: 467214-20-6
    纯度: >98.00%

    Water-soluble inhibitor of Hsp90

  • GC43649 structure
    GC43649Falcarinol
    CAS: 21852-80-2
    纯度: >70.00% / >98.00%

    Falcarinol是一种天然来源的口服Hsp90抑制剂。

  • GC45926 structure
    GC45926Nelfinavir-d3
    CAS: 1217629-70-3
    纯度: >99.00%

    An internal standard for the quantification of nelfinavir

  • GC48124 structure
    GC48124Tamoxifen-d5
    CAS: 157698-32-3
    纯度: >99.00%

    An internal standard for the quantification of tamoxifen

  • GC50153 structure
    GC50153BIX
    CAS: 101714-41-4
    纯度: >99.50%

    An inducer of GRP78

  • GC61563 structure
    GC61563Aminohexylgeldanamycin
    CAS: 485395-71-9

    Aminohexylgeldanamycin(AHGDM)，Geldanamycin的衍生物，是一种热休克蛋白90(HSP90)抑制剂。Aminohexylgeldanamycin具有抗血管生成和抗肿瘤活性。

  • GC61582 structure
    GC615823-Phenyltoxoflavin
    CAS: 32502-63-9
    纯度: >99.50%

    3-Phenyltoxoflavin是Toxoflavin的衍生物，是一种Hsp90抑制剂，抑制Hsp90-TPR2A之间相互作用的Kd值为585nM。3-Phenyltoxoflavin具有抗癌活性。

  • GC61784 structure
    GC61784HS-27
    CAS: 1562024-11-6
    纯度: >98.00%

    HS-27，一种荧光Hsp90抑制剂，检测完整组织标本表面Hsp90的表达。HS-27由SNX-5422的核心元素组成，SNX-5422是一种Hsp90抑制剂，通过PEG连接物与荧光素衍生物(异硫氰酸荧光素或FITC)连接，后者与外周表达的Hsp90结合。HS-27在乳腺癌的观察与研究中有潜在的应用。

  • GC62120 structure
    GC62120DTHIB
    CAS: 897326-30-6
    纯度: >98.00%

    DTHIB (Direct Targeted HSF1 InhiBitor) is a direct and selective inhibitor of heat shock factor 1 (HSF1) with Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB exhibits potently anticancer activities.

  • GC62305 structure
    GC62305DDO-5936
    CAS: 2355377-13-6
    纯度: >98.00%

    DDO-5936 是一种有效且特异的 Hsp90-Cdc37 PPI 抑制剂。DDO-5936 可用于大肠癌的研究。

  • GC62388 structure
    GC62388YUM70
    CAS: 423145-35-1
    纯度: >98.00%

    YUM70 is a potent inhibitor of glucose-regulated protein 78 (GRP78) inhibitor with an IC50 of 1.5 μM. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.Although YUM70 inhibits GRP78 enzymatic activity, it increases the expression of GRP78 by increasing the chaperone translation mechanism.

  • GC63282 structure
    GC63282Icapamespib
    CAS: 1000999-96-1

    Icapamespib (PU-HZ151) 是一种有效的 HSP90 抑制剂，EC50 值为5 nM. Icapamespib 可以透过血脑屏障。

  • GC63796 structure
    GC63796116-9e
    CAS: 831217-43-7
    纯度: >98.00%

    116-9e 是 Hsp40-Hsp70 结合的阻断剂，从而抑制 Hsp70-Hsp40 的伴侣活性。Hsp40 家族的辅助伴侣通过一个保守的 J 结构域与 Hsp70 结合。116-9e 通过阻止 Hsp70-Hsp40 复合物组装来抑制伴侣功能。

  • GC63852 structure
    GC63852Palmitic acid-d3
    CAS: 75736-53-7

    Palmitic acid-d3 是 Palmitic acid 的氘代物。Palmitic acid 是一种常见于动物和植物中的长链饱和脂肪酸。Palmitic acid 可以诱导小鼠颗粒细胞中葡萄糖调节蛋白 78 (GRP78) 和 CCAAT/增强子结合蛋白同源蛋白 (CHOP) 的表达。

  • GC64370 structure
    GC64370Kongensin A
    CAS: 885315-96-8
    纯度: >98.00%

    Kongensin A 是一种从 Croton kongensis 中分离的天然产物。 Kongensin A 是一种有效的，共价的 HSP90 抑制剂，可阻断 RIP3 依赖性坏死病。Kongensin A 是一种有效的坏死性抑制剂和凋亡诱导剂，并具有潜在的抗坏死性和消炎性应用。

  • GC64655 structure
    GC64655NXP800
    CAS: 1693734-80-3

    NXP800 (CCT361814) 是一种有效的热激因子 1 (HSF1) 抑制剂。NXP800 具有用于癌症研究的潜力。

  • GC64685 structure
    GC64685SNX-0723
    CAS: 1073969-18-2
    纯度: >99.00%

    SNX-0723 是一种 Hsp90 抑制剂，具有抗疟原虫活性。SNX-0723 对 HsHsp90 和 PfHsp90 具有高结合亲和力，Ki 分别为 4.4 和 47 nM。SNX-0723 抑制肝期伯氏疟原虫 ANKA 寄生虫，EC50 为 3.3 μM。

  • GC64714 structure
    GC64714NCT-58
    CAS: 2411429-33-7
    纯度: >99.00%

    NCT-58是 HSP90 C末端的有效抑制剂。NCT-58 不诱导热休克反应 (HSR)，因为它靶向 C 末端区域，并通过同时下调 HER 家族成员以及抑制 Akt 磷酸化来引发抗肿瘤活性。NCT-58 可杀死曲妥珠单抗耐药 (Trastuzumab-resistant) 的乳腺癌干细胞样细胞。NCT-58 诱导 HER2 阳性乳腺癌细胞凋亡。在抗曲妥珠单抗异种移植模型中，NCT-58 可抑制生长和血管生成。