GlpBio

Endogenous Metabolite

Endogenous Metabolite(内源性代谢物)

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Endogenous Metabolite 相关产品(1712)

  • GC47980 structure
    GC47980Propionyl-L-carnitine-d3 (chloride)
    CAS: 1334532-19-2
    纯度: >99.00%

    An internal standard for the quantification of propionyl-L-carnitine

  • GC48086 structure
    GC48086Solanesol
    CAS: 13190-97-1
    纯度: >90.00% / >95.00%

    A trisesquiterpenoid with diverse biological activities

  • GC48107 structure
    GC48107Stearoyl-L-carnitine-d3 (chloride)
    CAS: 2245711-27-5
    纯度: >99.00%

    An internal standard for the quantification of stearoyl-L-carnitine

  • GC48192 structure
    GC48192trans-2-Octenoyl-L-carnitine
    CAS: 152064-94-3
    纯度: >95.00%

    A synthetic carnitine

  • GC48440 structure
    GC484402'-Deoxycytidine-5'-triphosphate (sodium salt)
    CAS: 109909-44-6
    纯度: >95.00%

    A nucleoside triphosphate

  • GC48948 structure
    GC48948α-Ketoglutaric Acid (sodium salt)
    CAS: 22202-68-2
    纯度: >98.00%

    An intermediate in the citric acid cycle

  • GC50060 structure
    GC50060Cerestat
    CAS: 137160-11-3

    An NMDA receptor antagonist

  • GC50089 structure
    GC50089PEAQX tetrasodium salt
    纯度: >98.00%

    Potent and GluN2A-selective NMDA antagonist

  • GC50113 structure
    GC50113Noradrenaline bitartrate
    CAS: 51-40-1
    纯度: >99.00%

    Noradrenaline bitartrate是一种β1选择性肾上腺素受体激动剂，EC 50 值为5.37μM。

  • GC50134 structure
    GC50134Bengamide B
    CAS: 104947-69-5

    Potent inhibitor of NF-κB activation

  • GC50373 structure
    GC50373Retrobradykinin
    CAS: 5991-13-9

    逆缓激肽具有与缓激肽相反的序列。

  • GC60011 structure
    GC600111,3-Dithiane
    CAS: 505-23-7
    纯度: >98.00%

    1,3-二噻烷2位的亚甲基氢具有较高的酸度（pKa31.1），在烷基锂等强碱作用下可生成烷基阴离子物种。由于硫缩醛通过脱保护转化为羰基，1,3-二噻烷可用作酰基阴离子等价物（酰基极性改变）。也就是说，酮醛可以通过使亲核试剂如卤代烷反应然后将产物水解来获得。它也可以通过脱硫反应转化为烷烃。

  • GC60018 structure
    GC600182-Phenylacetaldehyde
    CAS: 122-78-1
    纯度: >98.00%

    Phenylacetaldehyde (Hyacinthin, Phenylethanal) is an organic compound used in the synthesis of fragrances and polymers.

  • GC60023 structure
    GC600233'-Deoxyuridine-5'-triphosphate
    CAS: 69199-40-2
    纯度: >98.00%

    3'-Deoxyuridine-5'-triphosphate(3'-dUTP)是一种核苷酸类似物，可抑制DNA依赖性RNA聚合酶I和II(RNApolymerasesI和II)，强烈并竞争性地抑制UTP掺入到RNA中，Ki值为2.0μM。

  • GC60125 structure
    GC60125D-Cysteine
    CAS: 921-01-7
    纯度: >98.00% / >97.00%

    D-Cysteine 是半胱氨酸的 D 型异构体，也是一种大肠杆菌生长的有力抑制剂。D-Cysteine 由 D-氨基酸氧化酶介导产生 H2S，并且是针对小脑共济失调的神经保护剂。D-Cysteine 可抑制由变形链球菌和血红链球菌形成的双物种生物膜的生长和致龋性。

  • GC60160 structure
    GC60160FAPy-adenine
    CAS: 5122-36-1
    纯度: >99.50%

    FAPy-adenine 是一种氧化的 DNA 碱基。FAPy-adenine 在阿尔茨海默病脑中呈上升趋势。氧化核苷是肿瘤、衰老和神经退行性疾病的生化标志物。

  • GC60170 structure
    GC60170Fructosyl-lysine
    CAS: 21291-40-7
    纯度: >97.00%

    Fructosyl-lysine (Fructoselysine) 是葡萄糖与赖氨酸通过美拉德反应生成的一种氨基糖基化产物 (amadori glycation)。Fructosyl-lysine 是葡萄糖烷的前体，葡萄糖烷是一种赖氨酸-精氨酸蛋白交联物，可作为糖尿病中检测的指标。

  • GC60224 structure
    GC60224L-Glyceric acid
    CAS: 28305-26-2

    L-Glycericacid是一种主要的尿代谢产物，在罕见的遗传性代谢疾病L-甘油酸尿症中积累。L-Glycericacid可用于诊断2型原发性高草酸尿症(PH2)，可用来区分PH1和PH2疾病。

  • GC60230 structure
    GC60230Lumisterol
    CAS: 474-69-1
    纯度: >99.00%

    Lumisterol(9β,10α-Ergosterol)，一种类固醇化合物，是一种Ergosterol的(9β,10α)-立体异构体。Lumisterol是一种抗紫外线诱导的DNA损伤和抗增殖活性的光保护剂。

  • GC60244 structure
    GC60244Mesoxalate sodium (monohydrate)
    CAS: 31635-99-1
    纯度: >99.00%

    Sodium mesoxalate monohydrate (sodium 2,2-dihydroxymalonate) is an endogenous metabolite.

  • GC60371 structure
    GC60371Trimethylammonium chloride
    CAS: 593-81-7
    纯度: >98.00%

    Trimethylammonium chloride 是一种内源性代谢产物。

  • GC60377 structure
    GC60377Urolithin C
    CAS: 165393-06-6
    纯度: >97.00%

    UrolithinC，是鞣花酸的多酚类肠道微生物代谢产物，是胰岛素分泌(insulinsecretion)的葡萄糖依赖性激活剂。UrolithinC是一种L型Ca2+通道开放剂，可增强Ca2+的流入。UrolithinC通过线粒体介导的途径诱导细胞凋亡(apoptosis)，并刺激活性氧(ROS)的形成。

  • GC60383 structure
    GC60383Vomifoliol
    CAS: 23526-45-6

    Vomifoliol是一种与脱落酸(ABA)有关的化合物，具有修饰的2,4-戊二烯侧链，其活性与ABA的活性相当。Vomifoliol表现出抗乙酰胆碱酯酶(antiacetylcholinesterase)活性和中等抗利什曼虫(antileishmanial)活性。

  • GC60404 structure
    GC60404(Ethoxymethyl)benzene
    CAS: 539-30-0
    纯度: >95.00%

    (Ethoxymethyl)benzene是一种内源性代谢产物。