GlpBio

Dipeptidyl Peptidase

Dipeptidyl Peptidase(二肽基肽酶)

Dipeptidyl Peptidase (DPP) is an antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation,signal transduction and apoptosis. DPP is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPP are proline-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP plays a major role in glucose metabolism. DPP is responsible for the degradation of incretins such as GLP-1. Furthermore, DPP appears to work as a suppressor in the development of cancer and tumours. DPP plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.

Dipeptidyl Peptidase 相关产品(49)

  • GC31467 structure
    GC31467Dutogliptin
    CAS: 852329-66-9
    纯度: >99.00%

    Dutogliptin是一种口服有效的选择性二肽基肽酶-4(DPP4)抑制剂。

  • GC31472 structure
    GC31472Retagliptin Phosphate (SP 2086)
    CAS: 1256756-88-3
    纯度: >99.50%

    Retagliptin Phosphate (SP 2086) (SP2086 phosphate) 是一种选择性、竞争性和口服活性的二肽基肽酶 4 (DPP-4) 抑制剂。

  • GC31492 structure
    GC31492Vildagliptin dihydrate (LAF237 dihydrate)
    CAS: 2133364-01-7

    A DPP-4 inhibitor

  • GC31547 structure
    GC31547DPP-IV-IN-1
    CAS: 625110-37-4

    DPP-IV-IN-1是一种有效的dipeptidylpeptidaseIV(DPP-IV)抑制剂，IC50值为4.6nM；DPP-IV为一种特异性的丝氨酸蛋白酶(serineprotease)。

  • GC32546 structure
    GC32546Prodipine hydrochloride
    CAS: 31314-39-3

    Prodipine是一种二苯基膦酸酯衍生物。抑制兔纯化的和血浆中的二肽基肽酶IV(DPPIV)，IC50分别为4.5μM和30μM。

  • GC33769 structure
    GC33769Gemigliptin (LC15-0444)
    CAS: 911637-19-9

    Gemigliptin (Zemiglo, LC15-0444) is a potent, selective and long-acting dipeptidyl peptidase 4 (DPP 4) inhibitor with a Ki of 7.25 nM. Gemigliptin shows at least >23,000-fold selectivity for DPP-4 over various proteases and peptidases, including DPP-8, DPP-9, and fibroblast activation protein (FAP)-α.

  • GC33853 structure
    GC33853Talabostat (PT100)
    CAS: 149682-77-9

    Talabostat (PT100)是一种口服活性的二肽基肽酶IV DPP-IV IC50 < 4 nM的非选择性抑制剂;Ki = 0.18 nM，临床首个成纤维细胞活化蛋白FAP抑制剂IC50= 560 nM，抑制DPP 8/9的IC50= 4/11 nM;Ki = 1.5/0.76 nM，脯氨酸内肽酶QPP IC50= 310 nM, DPP2等DASH家族酶。

  • GC37594 structure
    GC37594Saxagliptin hydrate
    CAS: 945667-22-1
    纯度: >99.00%

    Saxagliptin hydrate是一种高效二肽基肽酶-4（DPP-4）抑制剂，通过选择性抑制DPP-4酶，从而升高内源性胰高血糖素样肽-1（GLP-1）和葡萄糖依赖性促胰岛素释放多肽（GIP）的水平以调节血糖。

  • GC37757 structure
    GC37757Teneligliptin hydrobromide hydrate
    CAS: 1572583-29-9

    A DPP-4 inhibitor

  • GC39296 structure
    GC392961G244
    CAS: 847928-32-9
    纯度: >98.50%

    1G244 是一种有效的 DPP8/9 抑制剂，IC50 分别为 12 nM 和 84 nM，但不抑制 DPPIV 和 DPPII。1G244 可诱导多发性骨髓瘤细胞凋亡，并具有抗骨髓瘤作用。

  • GC44353 structure
    GC44353NDMC101
    CAS: 1308631-40-4
    纯度: >99.50%

    A salicylanilide derivative

  • GC44874 structure
    GC44874Saxagliptin (hydrochloride)
    CAS: 709031-78-7
    纯度: >98.00%

    A potent DPP-4 inhibitor

  • GC45436 structure
    GC45436Diprotin A
    CAS: 90614-48-5
    纯度: >99.00%

    A tripeptide inhibitor of DPP-4

  • GC47751 structure
    GC47751Nateglinide-d5
    CAS: 1227666-13-8
    纯度: >99.00%

    An internal standard for the quantification of nateglinide

  • GC60613 structure
    GC60613Azaleatin
    CAS: 529-51-1

    Azaleatin是一种从Rhododendron种中分离得到的O-甲基化黄酮醇。Azaleatin是二肽基肽酶-IV的抑制剂。Azaleatin可用于2型糖尿病和肥胖症的研究。

  • GC60828 structure
    GC60828Evogliptin tartrate
    CAS: 1222102-51-3
    纯度: >99.50%

    Evogliptintartrate是一种高效、口服有效、选择性的DPP-4抑制剂，具有抗糖尿病活性。Evogliptintartrate可用于靶向动脉炎症和动脉粥样硬化的研究。

  • GC62280 structure
    GC62280Teneligliptin D8
    CAS: 1391012-95-5

    Teneligliptin D8 (MP-513 D8) 一种氘标记的 Teneligliptin (MP-513)。Teneligliptin D8 (MP-513 D8) 是一种强效的、口服的、有竞争力的、持久的 DPP-4 抑制剂。

  • GC63170 structure
    GC63170Retagliptin
    CAS: 1174122-54-3
    纯度: >98.50%

    Retagliptin (SP2086) 是一种选择性的竞争性，且具有口服活性的二肽基肽酶 4 (DPP-4) 抑制剂。Retagliptin 可用于 2 型糖尿病 (T2DM) 的研究。

  • GC63383 structure
    GC63383Sitagliptin-d4 phosphate
    CAS: 1432063-88-1

    Sitagliptin-d4 (MK-0431-d4) phosphate 是 Sitagliptin phosphate 的氘代物。Sitagliptin phosphate (MK-0431 phosphate) 是一种有效的 DPP4 抑制剂，在 Caco-2 细胞中，IC50 值为 19 nM。

  • GC66355 structure
    GC66355Linagliptin-d4
    CAS: 2140263-92-7

    Linagliptin-d4 是 Linagliptin 氘代物。Linagliptin 是一种有效，选择性的 DPP-4 抑制剂，IC50 值为 1 nM。

  • GC68890 structure
    GC68890Cofrogliptin
    CAS: 1844874-26-5
    纯度: >99.00%

    Cofrogliptin (HSK7653) (compound 2)，一种四氢吡喃衍生物，是一种有效的口服 DPP-4 抑制剂，具有长效降糖作用。Cofrogliptin (compound 2) 在2型糖尿病 (T2DM) 应用中具有很大的潜力。

  • GC69900 structure
    GC69900Sitagliptin fenilalanil
    CAS: 1339955-03-1
    纯度: >99.00%

    Sitagliptin fenilalanil 是一种二肽氨基肽酶 (DPP-4) 抑制剂。

  • GC69901 structure
    GC69901Sitagliptin fenilalanil hydrochloride
    CAS: 1339954-75-4
    纯度: >98.50%

    Sitagliptin fenilalanil hydrochloride 是一种二肽氨基肽酶 (DPP-4) 抑制剂。

  • GC70545 structure
    GC70545Fotagliptin benzoate
    CAS: 1403496-40-1
    纯度: >99.00%

    Fotagliptin benzoate是二肽基肽酶IV（DPP-4）抑制剂（IC50=2.27nM）。