GlpBio

Aldehyde Dehydrogenase (ALDH)

Aldehyde Dehydrogenase (ALDH)(乙醛脱氢酶)

Aldehyde dehydrogenase 1 (ALDH1), which is a putative marker of breast cancer stem cells (CSCs), in triple negative breast cancer (TNBC) tissues.

Mitochondrial aldehyde dehydrogenase (ALDH2) is a member of the 19-strong human aldehyde dehydrogenase family of NADP+-dependent enzymes.

ALDH2, a mitochondrial enzyme responsible for metabolizing the major lipid peroxidation product, protects against acute ischemia/reperfusion injury and chronic heart failure. Activation of ALDH2, the main enzyme that catalyzes 4-HNE metabolism, is sufficient to protect the heart against acute ischemia-reperfusion injury.

ALDH2 is a key detoxifying enzyme. ALDH2 is most commonly associated with its role in ethanol metabolism, catalyzing the oxidation of ethanol-derived acetaldehyde to acetate.

Aldehyde Dehydrogenase (ALDH) 相关产品(30)

  • GC68635 structure
    GC68635ALDH3A1-IN-1
    CAS: 1039855-56-5

    ALDH3A1-IN-1 (Compound 18) 是一种有效的 ALDH3A1 抑制剂，IC50 为 1.61 μM。ALDH3A1-IN-1 作为单药或与多西紫杉醇联合研究，对患者来源的原发性前列腺肿瘤上皮细胞比 DEAB 更有效。

  • GC69260 structure
    GC69260IGUANA-1
    CAS: 2756014-25-0

    IGUANA-1 是一种高效的 ALDH1B1 抑制剂，ALDH1B1 则是一种促进结直肠癌和胰腺癌的线粒体酶。IGUANA-1 对癌细胞具有显著的抑制作用。

  • GC69342 structure
    GC69342KS100
    CAS: 2408477-54-1

    KS100 是一种有效的 ALDH 抑制剂，对 ALDH1A1、ALDH2 和 ALDH3A1 的 IC50 分别为 334、2137、360 nM。KS100 具有低毒性的抗增殖和抗癌作用。KS100 显著增加 ROS 活性、脂质过氧化和有毒醛的积累。KS100 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期。

  • GC71432 structure
    GC71432FSI-TN42
    CAS: 2445840-25-3
    纯度: >98.00%
  • GC72957 structure
    GC72957ALDH3A1-IN-3
    CAS: 315239-63-5
    纯度: >99.00%

    ALDH3A1-IN-3 (CB29)是ALDH3A1选择性抑制剂，Ki值为4.7 μM， IC50值为16 μM。

  • GC73645 structure
    GC73645YG1702
    CAS: 724737-08-0
    纯度: >99.00%

    YG1702是一种有效的aldh18a1特异性抑制剂。