GlpBio

NADPH Oxidase

NADPH Oxidase(NADPH氧化酶)

NADPH oxidase (NOX) is a transmembrane enzyme that is located in intracellular organelles. NADPH oxidase (NOX) enzymes are membrane-bound proteins that catalyze the conversion of oxygen to superoxide. There are a number of isoforms, NOX1-5 and dual oxidases 1 and 2 (DUOX1-2), which have diverse functions. NOX1, NOX2, NOX4, and NOX5 are expressed in human vascular tissue. NOX1 and NOX2 are regulated by cytosolic components loosely termed as activators or organizers, which are generally recruited to the membrane components following cellular stimuli to assemble an active NOX. Molecular switch from NOX1 to NOX2 in colon cancer cells induces ROS production and subsequently enhances MMP-7 expression by deactivating AMPK. Vascular NOX4 is a multifarious NADPH oxidase. NOX4 is a hydrogen peroxide-generating oxygen sensor.

NADPH Oxidase 相关产品(14)

  • GC11882 structure
    GC11882GKT137831
    CAS: 1218942-37-0
    纯度: >99.00%

    GKT137831是一种口服有效的双重NADPH氧化酶1/4（NOX1/NOX4）抑制剂，活性处于亚微摩尔范围，可预防高糖诱导的人主动脉内皮细胞氧化应激，并减轻糖尿病小鼠的动脉粥样硬化进展。

  • GC12291 structure
    GC12291ML 171
    CAS: 6631-94-3
    纯度: >99.50%

    A selective, cell-active Nox1 inhibitor

  • GC12323 structure
    GC12323ML-090
    CAS: 531-46-4
    纯度: >95.00% / >98.00%

    A selective NOX1 inhibitor

  • GC12520 structure
    GC12520Diphenyleneiodonium chloride
    CAS: 4673-26-1
    纯度: >99.50%

    二苯碘铵 (DPI) 氯化物 (DPIC) 作为 NADH/NADPH 氧化酶抑制剂，对 Mtb 和 S. aureus 具有有效的抗菌活性。

  • GC31367 structure
    GC31367GLX351322
    CAS: 835598-94-2
    纯度: >99.50%

    GLX351322是一种NADPH氧化酶4 (NOX4)抑制剂，IC 50 值为5μM。

  • GC32443 structure
    GC32443VAS2870
    CAS: 722456-31-7
    纯度: >98.50%

    A pan-NADPH oxidase inhibitor

  • GC32681 structure
    GC32681GSK2795039
    CAS: 1415925-18-6
    纯度: >99.50% / >98.00%

    GSK2795039是一种强效NADPH氧化酶2（NOX2）抑制剂，IC 50 值为0.18μM。

  • GC38115 structure
    GC38115APX-115 free base
    CAS: 1270084-92-8
    纯度: >99.00%

    Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.

  • GC38353 structure
    GC38353APX-115
    CAS: 1395946-75-4
    纯度: >98.00%

    APX-115 (Ewha-18278) 是一种有效的，口服活性的，非选择性 Nox 抑制剂，对 Nox1，Nox2 和 Nox4 的 Ki 值分别为 1.08 μM，0.57 μM 和 0.63 μM。APX-115 可有效预防糖尿病小鼠的肾损伤。

  • GC50281 structure
    GC50281NoxA1ds
    CAS: 1435893-78-9
    纯度: >98.50%

    NoxA1ds 是一种高效和选择性的 Nox1（NADPH 氧化酶异构体 1）抑制剂。

  • GC62989 structure
    GC62989GKT136901 hydrochloride
    CAS: 1254507-01-1
    纯度: >99.50%

    A dual inhibitor of NOX1 and NOX4

  • GC63986 structure
    GC63986VAS 3947
    CAS: 869853-70-3
    纯度: >99.00%

    VAS 3947 是一种特异的 NADPH 氧化酶 (NOX) 抑制剂，具有强大的抗血小板作用。VAS 3947 通过 UPR 激活，主要由于蛋白质聚集和错误折叠，独立于抗 NOX 活性诱导细胞凋亡 (apoptosis)。

  • GC71188 structure
    GC71188NADPH oxidase-IN-1
    CAS: 2762405-17-2
    纯度: >99.00%

    NADPH oxidase-IN-1是一种与神经元炎症相关的口服活性NADPH氧化酶（Nox）抑制剂。

  • GC71289 structure
    GC71289GLX481304
    CAS: 701224-63-7
    纯度: >99.00%

    GLX481304是Nox-2和-4的特异性抑制剂，ic50为1.25 μM。