GlpBio

APX-115 free base

目录号: GC38115纯度: >99.00%同义词: Ewha-18278 free base
Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.
APX-115 free base
Cas No.: 1270084-92-8
规格价格库存数量操作
5mg¥1,080.00现货
1
10mg¥1,800.00现货
1
25mg¥3,780.00现货
1
10mM (in 1mL DMSO)¥1,660.00现货
1
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文献被引

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产品描述 Description

Isuzinaxib (APX-115 free base, Ewha-18278 free base) is a potent, orally active inhibitor of pan NADPH oxidase (pan-Nox) with Ki of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base (Ewha-18278 free base) significantly suppresses the expression of inflammatory molecules including MCP-1/CCL2, IL-6, and TNFα in the diabetic kidney.

[1] Jung Hee Joo, et al. Sci Rep. 2016 Mar 15;6:22389. [2] Jin Joo Cha, et al. Lab Invest. 2017 Apr;97(4):419-431.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
1270084-92-8
同义词
Ewha-18278 free base
SMILES
OC1=C(CCC)C(C2=CC=CC=C2)=NN1C3=NC=CC=C3
分子式
C17H17N3O
分子量
279.34 g/mol
溶解性
DMSO: 250 mg/mL (894.97 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol