GlpBio

Aryl Hydrocarbon Receptor

Aryl Hydrocarbon Receptor(芳烃受体)

Aryl Hydrocarbon Receptor (AhR or AHR or ahr or ahR) is a protein that in humans is encoded by the AHR gene. The aryl hydrocarbon receptor is a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic (aryl) hydrocarbons, and regulates xenobiotic-metabolizing enzymes such as cytochrome P450s, most notably cyp 1A1.

Aryl Hydrocarbon Receptor is a member of the family of basic helix-loop-helix transcription factors. AhR binds several exogenous ligands including natural plant flavonoids, polyphenolics and indoles, as well as synthetic polycyclic aromatic hydrocarbons and dioxin-like compounds. AhR is a cytosolic transcription factor that is normally inactive, binding to several co-chaperones. Upon ligand binding to chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the chaperones dissociate resulting in AhR translocating into the nucleus and dimerizing with ARNT (AhR nuclear translocator), leading to changes in gene transcription.

Aryl Hydrocarbon Receptor 相关产品(35)

  • GC10538 structure
    GC10538Pifithrin-α (PFTα)
    CAS: 63208-82-2
    纯度: >98.00%

    Pifithrin-α是一种p53抑制剂。

  • GC11817 structure
    GC11817PDM 2
    CAS: 688348-25-6
    纯度: >98.50%

    A resveratrol-based aryl hydrocarbon receptor antagonist

  • GC12040 structure
    GC12040L-Kynurenine
    CAS: 2922-83-0
    纯度: >98.00%

    L-Kynurenine是L-色氨酸的代谢物，也是一种芳香烃受体 (aryl hydrocarbon receptor; AhR) 激动剂。

  • GC12628 structure
    GC12628ITE
    CAS: 448906-42-1
    纯度: >99.00%

    ITE是一种有效的免疫抑制性内源性芳香烃受体（AhR）激动剂，与AhR结合的K i 值为3nM。

  • GC16220 structure
    GC16220CH 223191
    CAS: 301326-22-7
    纯度: >98.50% / >98.00%

    CH 223191是一种有效且特异性的芳烃受体（AhR）拮抗剂，可抑制TCDD介导的AhR核转位和DNA结合，并抑制TCDD诱导的荧光素酶活性，IC50为0.03 μM。

  • GC16368 structure
    GC16368Indole-3-carbinol
    CAS: 700-06-1
    纯度: >98.00%

    A natural phytochemical

  • GC17043 structure
    GC17043StemRegenin 1 (SR1)
    CAS: 1227633-49-9
    纯度: >98.00%

    StemRegenin 1 (SR1)是一种强效芳香烃受体（AhR）拮抗剂（IC 50 = 127nM）。

  • GC18824 structure
    GC18824CAY10465
    CAS: 688348-33-6
    纯度: >98.00%

    A resveratrol-based aryl hydrocarbon receptor agonist

  • GC30297 structure
    GC30297Mivotilate (YH439)
    CAS: 130112-42-4
    纯度: >98.00%

    Mivotilate (YH439) 是一种无毒、有效的芳烃受体 (AhR) 激活剂，可作为保肝剂。

  • GC30646 structure
    GC30646Skatole(3-Methylindole)
    CAS: 83-34-1
    纯度: >99.50%

    Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.

  • GC31732 structure
    GC31732Tapinarof (WBI 1001)
    CAS: 79338-84-4
    纯度: >99.50%

    Tapinarof (GSK2894512, Benvitimod, WBI 1001, DHPS, DMVT 505) is a natural agonist of aryl hydrocarbon receptor (AhR) and induces nuclear translocation of AhR in immortalized keratinocytes (HaCaT) with EC50 of 0.16 nM. Tapinarof induces cellular apoptosis in CD4+ T cells in a dosedependent manner with IC50 of 5.2 μM.

  • GC33314 structure
    GC333141,4-Chrysenequinone (Chrysene-1,4-dione)
    CAS: 100900-16-1

    1,4-Chrysenequinone (Chrysene-1,4-dione) 是一种多环芳香族醌，可作为芳烃受体 (AhR) 的激活剂。

  • GC34597 structure
    GC34597GNF351
    CAS: 1227634-69-6
    纯度: >99.50%

    GNF351 is a potent antagonist of aryl hydrocarbon receptor (AHR). GNF351 interacts directly with the AHR ligand binding pocket and competes with a well-characterized photoaffinity AHR ligand for binding to the AHR with IC50 of 62 nM.

  • GC35271 structure
    GC35271BAY-218 (AHR antagonist 1)
    CAS: 2162982-11-6
    纯度: >99.00%

    BAY-218 (AHR antagonist 1)是一种新型的、选择性的、强效的AhR小分子抑制剂。BAY-218能够抑制AhR核转位、二噁英反应元件（DRE）-荧光素酶报告基因表达，以及由外源性和内源性AhR配体诱导的AhR调节靶基因表达。

  • GC35553 structure
    GC35553Brevifolincarboxylic acid
    CAS: 18490-95-4
    纯度: >99.50%

    A phenol with anticancer and anti-inflammatory activities

  • GC36043 structure
    GC36043FICZ
    CAS: 172922-91-7
    纯度: >98.00%

    FICZ（甲酰吲哚 咔唑）作为芳基烃受体 (AhR) 的内源性配体，可以发挥多效性作用，包括防止炎症、纤维化和氧化应激。

  • GC39284 structure
    GC39284ANI-7
    CAS: 931417-26-4
    纯度: >99.00%

    ANI-7 是一种 AhR 途径的激活剂。ANI-7 抑制多种癌细胞的生长，并有选择地抑制 MCF-7 乳腺癌细胞的生长，GI50 为 0.56 μM。ANI-7 通过激活 AhR 途径诱导 CYP1 代谢单加氧酶，并在敏感的乳腺癌细胞系中诱导 DNA 损伤，检查点激酶 (Chk2) 激活，S 期细胞周期停滞和细胞死亡。

  • GC39669 structure
    GC39669AHR antagonist 2
    CAS: 2338747-54-7
    纯度: >99.00%

    AHR antagonist 2 是一种有效的芳香烃受体 (AHR) 拮抗剂，对人和小鼠的 IC50 值分别为 0.885，2.03 nM，详情请参见专利 WO2019101641A1，example 1。

  • GC44686 structure
    GC44686Prochloraz
    CAS: 67747-09-5
    纯度: >98.00%

    An imidazole antifungal

  • GC45705 structure
    GC45705D-Kynurenine
    CAS: 13441-51-5
    纯度: >98.50%

    An antagonist of GPR109B

  • GC47037 structure
    GC47037Carbidopa (hydrate)
    CAS: 38821-49-7
    纯度: >98.00%

    Carbidopa (hydrate)是一种aryl hydrocarbon receptor (AhR)激动剂，可抑制胰腺癌细胞和肿瘤的生长。

  • GC50422 structure
    GC5042210-Cl-BBQ
    CAS: 23982-76-5

    Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable

  • GC60636 structure
    GC60636Benzyl butyl phthalate
    CAS: 85-68-7
    纯度: >97.00%

    Benzylbutylphthalate是邻苯二甲酸酯(PAEs)的一员，通过上调Zeb1的表达，可引起血管瘤(HA)细胞的迁移和侵袭。Benzylbutylphthalate激活乳腺癌细胞中的芳香烃受体(AhR)，刺激SPHK1/S1P/S1PR3信号传导，促进转移性乳腺癌干细胞(BCSCs)的形成。

  • GC64208 structure
    GC64208AHR antagonist 5 free base
    CAS: 2247950-42-9

    AHR antagonist 5 free base 是一种选择性的、具有口服活性的芳烃受体 (AHR) 抑制剂。AHR antagonist 5 free base 有效阻止 AHR 从细胞质转移到细胞核。AHR antagonist 5 free base 对 AHR 的选择性高于其他受体、转运蛋白和激酶，并具有抗癌作用。