GlpBio

DNA Methyltransferase

DNA Methyltransferase(DNA甲基转移酶)

DNA methyltransferases (DNMTs) are a family of enzymes that catalyze the transfer of a methyl group from the methyl donor, usually S-adenosyl-L-methionine (SAM) for all known DNMTs, to the 5-position of cytosine residues in DNA. In mammals, four members of the DNMT gene family have been identified and designated, DNMT1, DNMT3A, DNMT3B and DNMT3L respectively, in which DNMT1 encodes the maintenance methyltransferase, DNMT3A/3B encode the de novo methyltransferases, and DNMT3L encodes an enzyme without any inherent enzymatic activity. Mammalian DNMTs are involved in transcriptional silencing of several sequence classes and play an important role in maintaining genome stability and genomic integrity.

DNA Methyltransferase 相关产品(32)

  • GC64733 structure
    GC64733Procainamide
    CAS: 51-06-9
    纯度: >97.00%

    An Analytical Reference Standard

  • GC65242 structure
    GC65242TFMB-(S)-2-HG
    CAS: 1445703-64-9

    TFMB-(S)-2-HG 是 5'-甲基胞嘧啶羟化酶 TET2 的有效抑制剂。TFMB-(S)-2-HG 也抑制 EglN 脯氨酰羟化酶。TFMB-(S)-2-HG 具有研究急性髓性白血病 (AML) 的潜力。

  • GC65546 structure
    GC65546DNMT3A-IN-1
    CAS: 1403598-56-0

    DNMT3A-IN-1 是一种有效的选择性 DNMT3A 抑制剂。 DNMT3A-IN-1 显示出针对 DNMT3A 的抑制剂活性，KI 值范围为 9.16-18.85 μM (AdoMet) 和 11.37-23.34 μM (poly dI-dC)[1] 。

  • GC69030 structure
    GC69030DY-46-2
    CAS: 1105110-83-5
    纯度: >98.00%

    DY-46-2 是一种高效、选择性高的新型非核苷 DNA 甲基转移酶 3A (DNMT3A) 抑制剂，其IC50 值为 1.3 μM。

  • GC69194 structure
    GC69194GSK3735967
    CAS: 2170136-86-2
    纯度: >99.00%

    GSK3735967 是一种选择性、可逆、非核苷类 DNMT1 抑制剂。GSK3735967 含有一个平面二氰基吡啶核心，能特异性地嵌入 DNMT1 结合的半甲基化 CpG 二核苷酸中。GSK3735967 有三个结合位点，其中一个能与组蛋白 H4K20me3 结合。

  • GC73073 structure
    GC730735-Aza-4'-thio-2'-deoxycytidine
    CAS: 169514-76-5
    纯度: >99.00%

    5-Aza-4'-thio-2'-deoxycytidine（5-Aza-T-dCyd）是一种口服活性DNA转移酶I（DNMT1）抑制剂。

  • GC73949 structure
    GC73949METTL16-IN-1
    纯度: >99.00%

    METTL16-IN-1（化合物45）是一种有效的METTL16抑制剂，IC50值为1.7μM，Kd值为1.35μM。

  • GC73972 structure
    GC73972METTL1-WDR4-IN-2
    CAS: 2919742-07-5
    纯度: >99.00%

    METTL1-WDR4-IN-2（化合物6）是一种选择性金属转移酶样1（METTL1）-WDR4抑制剂，IC50为41μM。