GlpBio

Thymidylate Synthase

Thymidylate Synthase(胸苷酸合成酶)

Thymidylate synthase (TS) is an enzyme catalyzing the sole de novo pathway for the biosynthesis of deoxythymidine monophosphate (dTMP) in which deoxyuridine monophosphate (dUMP) is reductively methylated by 5,10-methylenetetrahydrofolate (CH2H4folate) with the generation of dTMP and dihydrofolate (H2folate). TS has been found in a wide range of sources, including bacteria, bacteriophage, yeast, viruses and vertebrates, where it is usually a dimer consisting of identical subunits (30 to 35 kDa each). However, protozoal TS is a bifunctional protein with dihydrofolate reductase (DHFR) on the same polypeptide chain, where TS and DHFR domains are located on the carboxy terminus and amino terminus respectively.

Thymidylate Synthase 相关产品(10)

  • GC11099 structure
    GC11099Doxifluridine
    CAS: 3094-09-5
    纯度: >99.50%

    An antitumor prodrug of 5-fluorouracil

  • GC11610 structure
    GC11610Pemetrexed
    CAS: 150399-23-8
    纯度: >99.50% / >98.00% / >99.00%

    An antifolate with anticancer activity

  • GC13803 structure
    GC13803Triflurdine (Viroptic)
    CAS: 70-00-8
    纯度: >99.50%

    A thymidine analog that inhibits DNA synthesis

  • GC14681 structure
    GC14681Nolatrexed (AG-337)
    CAS: 152946-68-4
    纯度: >98.50%

    A thymidylate synthase inhibitor

  • GC17750 structure
    GC17750Raltitrexed
    CAS: 112887-68-0
    纯度: >98.50% / >98.00%

    An inhibitor of thymidylate synthase

  • GC19348 structure
    GC19348TAS-102
    CAS: 733030-01-8
    纯度: >98.00%

    An orally bioavailable combination of a nucleoside analog and TPase inhibitor

  • GC37798 structure
    GC37798Tipiracil
    CAS: 183204-74-2

    A potent TPase inhibitor

  • GC62645 structure
    GC62645Fosifloxuridine nafalbenamide
    CAS: 1332837-31-6
    纯度: >98.00%

    Fosifloxuridine nafalbenamide (NUC-3373) 属于嘧啶核苷酸类似物，是一种胸腺嘧啶合酶 (Thymidylate synthase) 抑制剂。Fosifloxuridine nafalbenamide 具有抗癌活性。Fosifloxuridine nafalbenamide 具有诱发宿主免疫反应和增强免疫治疗的潜力。

  • GC64726 structure
    GC6472610-Formyl-5,8-dideazafolic acid
    CAS: 61038-31-1
    纯度: >96.00%

    10-Formyl-5,8-dideazafolic acid 是一种胸苷酸合成酶 (thymidylate synthase) 抑制剂。

  • GC17694 structure
    GC17694Pemetrexed disodium hemipenta hydrate
    CAS: 357166-30-4
    纯度: >99.00%

    Pemetrexed disodium hemipenta hydrate 是一种新型抗叶酸剂，LY231514 的五谷氨酸的 Ki 值分别为 1.3、7.2 和 65 nM，用于抑制胸苷酸合酶 (TS)、二氢叶酸还原酶 (DHFR) 和甘氨酰胺核糖核苷酸甲酰转移酶 (GARFT)。