GlpBio

Survivin

Survivin(生存素)

Survivin is the smallest member of the inhibitor of apoptosis (IAP) protein family, a family of highly conserved cell apoptosis inhibitors characterized by the presence of a zinc-binding fold (the baculoviral IAP repeat), that is comprised of a single N-terminal BIR domain, a long C-terminal α-helix coiled region and a dimeric arrangement. Survivin is a bifunctional protein, apart from its ability to inhibit apoptosis, which also plays an essential role in proper cell division. Survivin is not expressed in most normal and terminally differentiated adult tissues but expressed in fetal tissues, where its expression is cell cycle-regulated and peaks at mitosis.

Survivin 相关产品(8)

  • GC13107 structure
    GC13107YM155
    CAS: 781661-94-7
    纯度: >98.00%

    YM155是一种基于imidazolium的小分子化合物，能有效抑制survivin启动子活性，IC 50 值为0.54nM。

  • GC15632 structure
    GC15632YM-155 hydrochloride
    CAS: 355406-09-6

    A survivin inhibitor

  • GC33097 structure
    GC33097GDP366
    CAS: 501698-03-9
    纯度: >99.50%

    GDP366是survivin和Op18的双重抑制剂，抑制癌细胞生长，诱导细胞衰老和有丝分裂突变。

  • GC35758 structure
    GC35758Cucurbitacin IIa
    CAS: 58546-34-2
    纯度: >99.00%

    Curcurbitacin IIA (Cucurbitacin Iia, CuIIa, Hemslecin A, Dihydrocucurbitacin Q1) is the major active component of the Helmseya amabilis root and is known to have antiviral and anti-inflammatory effects.

  • GC60229 structure
    GC60229LQZ-7I
    CAS: 195822-23-2
    纯度: >99.50%

    An inhibitor of survivin

  • GC69884 structure
    GC69884Shepherdin (79-87) (TFA)
    纯度: >98.00%

    Shepherdin (79-87) TFA 是 Shepherdin 的 79 至 87 氨基酸片段。Shepherdin 是一种 Hsp90-Survivin 复合物的拟肽拮抗剂。具有抗肿瘤活性。

  • GC72933 structure
    GC72933LQZ-7F
    CAS: 354543-09-2
    纯度: >97.00%

    LQZ-7F是一种survivin二聚化抑制剂，在前列腺癌细胞中诱导自发凋亡并与多西他赛协同作用。

  • GC73986 structure
    GC73986MX106-4C
    纯度: >98.00%

    MX106-4C是一种选择性杀死abcb1阳性结直肠癌细胞的survivin抑制剂。