R 59-022 hydrochloride

目录号: GC69792纯度: >98.00%同义词: DKGI-I hydrochloride; Diacylglycerol kinase inhibitor I hydrochloride
R 59-022 (DKGI-I) hydrochloride 是一种 DGK 抑制剂 (IC50: 2.8 µM)。R 59-022 hydrochloride 抑制 OAG 磷酸化为 OAPA。R 59-022 hydrochloride 是一种 5-HT Receptor 拮抗剂,可激活蛋白激酶 C (PKC)。R 59-022 增强血小板中凝血酶诱导的甘油二酯的产生,并抑制嗜中性粒细胞中磷脂酸的产生。

R 59-022 hydrochloride
Cas No.: 93076-98-3
规格价格库存数量操作
10mg¥1,620.00现货
1
25mg¥3,240.00现货
1
50mg¥5,220.00现货
1

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产品描述 Description

R 59-022 (DKGI-I) drochloride is a Increased median survival and decreased tumor volume.

[1]. de Chaffoy de Courcelles, D.C., et al. R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet. J. Biol. Chem. 260(29), 15762-15770 (1985).
[2]. Nunn DL, et al. A diacylglycerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets. Biochem J. 1987 May 1;243(3):809-13.
[3]. Jones JA, et al. Influence of phorbol esters, and diacylglycerol kinase and lipase inhibitors on noradrenalinerelease and phosphoinositide drolysis in chromaffin cells. Br J Pharmacol. 1990 Nov;101(3):521-6.
[4]. Boroda S, et al. Dual activities of ritanserin and R59022 as DGKα inhibitors and serotonin receptor antagonists. Biochem Pharmacol. 2017 Jan 1;123:29-39.
[5]. Stewart CM, et al. A Diacylglycerol Kinase Inhibitor, R-59-022, Blocks Filovirus Internalization in Host Cells. Viruses. 2019 Mar 1;11(3). pii: E206.
[6]. Dominguez CL, et al. Diacylglycerol kinase α is a critical signaling node and novel therapeutic target in glioblastoma and other cancers. Cancer Discov. 2013 Jul;3(7):782-97.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
93076-98-3
同义词
DKGI-I hydrochloride; Diacylglycerol kinase inhibitor I hydrochloride
分子式
C27H27ClFN3OS
分子量
496.04 g/mol
溶解性
DMSO : 25 mg/mL (50.40 mM; Need ultrasonic)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至 37°C,然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备 RT,或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol